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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Hydrolytic DNA Cleavage by Non-Lanthanide Metal Complexes

Author(s): Thomas A. Shell and Debra L. Mohler

Volume 11, Issue 17, 2007

Page: [1525 - 1542] Pages: 18

DOI: 10.2174/138527207782418654

Price: $65


Metal complexes that hydrolyze DNA are important, due to their potential use as therapeutic agents, tools in elucidating oligonucleotide structure, and models for naturally-occurring metalloprotein nucleases. Therefore, this review focuses on recent advances in the hydrolysis of DNA and phosphate diester model compounds by non-lanthanide metal complexes.

Keywords: Mononuclear Cobalt Complexes, DNA cleavage, Zinc Complexes, Transition Metal, Dinuclear Iron

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