Targeting the NLRP3 Inflammasome in Diabetic Nephropathy

Title:Targeting the NLRP3 Inflammasome in Diabetic Nephropathy

Volume: 28 Issue: 42

Author(s): Ming Yang*, Xi Wang*, Yachun Han, Chenrui Li, Ling Wei, Jinfei Yang, Wei Chen, Xuejing Zhu and Lin Sun*

Affiliation:

• Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China

• Department of Nutrition, Xiangya Hospital, Central South University, Changsha, Hunan, China

• Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, Hunan, China

Keywords: NLRP3 inflammasome, diabetic nephropathy (DN), inflammation, structure of the NLRP3, end-stage renal disease (ESRD), DN progression.

Abstract: Diabetic nephropathy (DN) is one of the most common complications of diabetes and the main cause of end-stage renal disease (ESRD). The inflammatory response plays a key role in the pathological process of DN. As the most deeply studied inflammasome, NLRP3 should not be overlooked in DN. Its abnormal activation accelerates DN progression. In this review, we summarize our understanding of the structural composition and activation factors of the NLRP3 inflammasome. Moreover, the relationship between NLRP3 inflammasome activation, and the potential of the NLRP3 inflammasome as a therapeutic target for DN will also be discussed.

Cite this article as:

Yang Ming *, Wang Xi *, Han Yachun , Li Chenrui , Wei Ling , Yang Jinfei , Chen Wei , Zhu Xuejing and Sun Lin *, Targeting the NLRP3 Inflammasome in Diabetic Nephropathy, Current Medicinal Chemistry 2021; 28 (42) . https://dx.doi.org/10.2174/0929867328666210705153109