Apoptosis and Apoptosis-Based Therapy in Lung Cancer

Title: Apoptosis and Apoptosis-Based Therapy in Lung Cancer

Volume: 9 Issue: 9

Author(s): Cheng-Xiong Xu, Hua Jin and Myung-Haing Cho

Affiliation:

Keywords: Lung cancer, apoptosis, anticancer agent

Abstract: Apoptosis is natural process in the development and maintenance of multicellular organisms. However, tumor cells often have faulty apoptotic pathways. The defects of apoptosis are partially caused by mutation and aberrant expression of apoptotic proteins. The apoptosis inactivation is implicated with both tumorigenesis and drug resistance. In addition, as compared to small-cell lung cancers, non-small cell lung cancers are less sensitive to radiation treatment or chemotherapy. Therefore, understanding the mechanisms of apoptosis induction in lung cancer cells is very important for anti-lung cancer drug development and lung cancer therapy. In this review, we discussed about the apoptosis mechanisms and altered apoptosis regulators expression and gene mutation in lung cancer.

Cite this article as:

Xu Cheng-Xiong, Jin Hua and Cho Myung-Haing, Apoptosis and Apoptosis-Based Therapy in Lung Cancer, Anti-Cancer Agents in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/187152009789377682