Abstract
In recent years, the broad utilization of high-throughput experimental techniques resulted in a vast amount of expression and interaction data, accompanied by information on metabolic, cell signaling and gene regulatory pathways accumulated in the literature and databases. Thus, one of the major goals of modern bioinformatics is to process and integrate heterogeneous biological data to provide an insight into the inner workings of a cell governed by complex interaction networks. The paper reviews the current development of semantic network (SN) technologies and their applications to the integration of genomic and proteomic data. We also elaborate on our own work that applies a semantic network approach to modeling complex cell signaling pathways and simulating the cause-effect of molecular interactions in human macrophages. The review is concluded with a discussion of the prospective use of semantic networks in bioinformatics practice as an efficient and general language for data integration, knowledge representation and inference.
Keywords: Semantic networks, biological data integration, protein interactions, knowledge representation, ontology, semantic web
Call for Papers in Thematic Issues
AI-Based Prediction of Functional Proteins
Functional proteins are vital molecules involved in a variety of physiological and pathological processes within the body. Understanding the relationship between protein structure and function is key to unraveling the mechanisms of life sciences, disease processes, and drug discovery. However, traditional experimental methods are often time-consuming, costly, and constrained by ...read more
Hot Topics in Computational Genomics
Computational genomics has emerged since the beginning of the 21st century. Recently, along with the sequencing technology at single-cell level, computational genomics step forward to the level of singe-cell resolution. Several topics are well studied in this area. Several other topics are still challenging tasks for bioinformatics. This thematic issue ...read more
Related Books
Wild Vegetables: Morphology, Phytochemistry and Utility Part 1
Biology for Students
Medicinal Plants of Pilibhit Tiger Reserve (PTR) India
Plant-Microbe Interactions: A Comprehensive Review
Glycosylation and Glycation in Health and Diseases
Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production
Methods and Techniques in Nematology
Mind Maps in Clinical Biochemistry
A Treatise on Ecological Science
From SARS-CoV to MARS-CoV
2
