Abstract
Temporin-1Vb, -1Oe, -1DRb, and -1TGb (10-8 - 10-6M) produced significant (p < 0.05) and concentrationdependent stimulatory effects on insulin secretion from clonal rat BRIN-BD11 cells without increased release of lactate dehydrogenase. Temporin-1Va and temporin-1Vc (10-8 - 10-6M) also stimulated insulin-release but were cytotoxic at 10-6M. Temporin-1DRa was without effect. The temporins at 10-7 M had no effect on intracellular calcium concentrations suggesting that they stimulate insulin release via a KATP channel- independent pathway.
Keywords: Amphibian skin, insulin secretion, temporin, cytolysis
Protein & Peptide Letters
Title: Insulin Releasing Properties of the Temporin Family of Antimicrobial Peptides
Volume: 14 Issue: 7
Author(s): Yasser H.A. Abdel-Wahab, Lamin Marenah, Peter R Flatt and J. Michael Conlon
Affiliation:
Keywords: Amphibian skin, insulin secretion, temporin, cytolysis
Abstract: Temporin-1Vb, -1Oe, -1DRb, and -1TGb (10-8 - 10-6M) produced significant (p < 0.05) and concentrationdependent stimulatory effects on insulin secretion from clonal rat BRIN-BD11 cells without increased release of lactate dehydrogenase. Temporin-1Va and temporin-1Vc (10-8 - 10-6M) also stimulated insulin-release but were cytotoxic at 10-6M. Temporin-1DRa was without effect. The temporins at 10-7 M had no effect on intracellular calcium concentrations suggesting that they stimulate insulin release via a KATP channel- independent pathway.
Export Options
About this article
Cite this article as:
Yasser H.A. Abdel-Wahab , Lamin Marenah , Peter R Flatt and J. Michael Conlon , Insulin Releasing Properties of the Temporin Family of Antimicrobial Peptides, Protein & Peptide Letters 2007; 14 (7) . https://dx.doi.org/10.2174/092986607781483822
| DOI https://dx.doi.org/10.2174/092986607781483822 |
Print ISSN 0929-8665 |
| Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
Call for Papers in Thematic Issues
Advancing the Understanding of Regulatory Mechanisms and Diseases Through Biochemistry and Structural Biology
Modern research is increasingly interested in understanding the regulatory mechanisms and diseases through various integrative approaches. Biochemistry and structural biology offer valuable atomic-level insights that help unravel the complexities of cellular regulatory mechanisms and their association with health and disease. The unique advantage of these fields is that they provide ...read more
Protein Based Biomaterials in Environmental Sustainability, Therapy, and Diagnostics
Protein-based biomaterials have wide variety of therapeutic and diagnostic applications. Important properties of these materials are biocompatibility, biodegradability, functional versatility, and ability to interact with life. They are biodegradable so make sought after targets for environmental applications. These materials are also being investigated for increased applications in water filtration technology ...read more
Recent Advances in Protein Engineering and Design
Protein engineering and design have revolutionized biotechnology, medicine, and industrial applications by enabling the creation of novel proteins with tailored functions. Recent advancements in computational modeling, directed evolution, and synthetic biology have expanded the possibilities for engineering proteins with enhanced stability, specificity, and activity. This special issue will explore state-of-the-art ...read more
Therapeutic Proteins and Peptides of Plant Origin
Plants are still the major repository of biologically active substances. In the last two decades, however, natural peptides and proteins of plant origin have gained increasing attention due to their pharmacological activities over a variety of human illnesses, including those mediated by infections and parasitosis and those involving different cellular ...read more
Related Journals
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Curcumin-based Nanoformulations to Target Breast Cancer: Current
Trends and Challenges
Current Nanomaterials Recent Advances in Elucidating Paclitaxel Resistance Mechanisms in Non-small Cell Lung Cancer and Strategies to Overcome Drug Resistance
Current Medicinal Chemistry A Short Overview on the Medicinal Chemistry of (—)-Shikimic Acid
Mini-Reviews in Medicinal Chemistry Recent Advances in the Probe Development of Technetium-99m Molecular Imaging Agents
Current Organic Synthesis Lipid-lowering Drug Therapy in Elderly Patients
Current Pharmaceutical Design Spin Trapping: An Essential Tool for the Study of Diseases Caused by Oxidative Stress
Current Topics in Medicinal Chemistry Benzoxazine: A Privileged Scaffold in Medicinal Chemistry
Current Medicinal Chemistry Synthesis and Pharmacological Effects of the Anti-Cancer Agent 2-Methoxyestradiol
Current Pharmaceutical Design Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs
Recent Patents on Cardiovascular Drug Discovery Apixaban: A New Player in the Anticoagulant Class
Current Drug Targets Prodrugs of Quercetin and Resveratrol: A Strategy Under Development
Current Drug Metabolism More Effective DPP4 Inhibitors as Antidiabetics Based on Sitagliptin Applied QSAR and Clinical Methods
Current Computer-Aided Drug Design Natural Antioxidants: Therapeutic Prospects for Cancer and Neurological Diseases
Mini-Reviews in Medicinal Chemistry Cardiovascular Effects of Coumarins Besides their Antioxidant Activity
Current Topics in Medicinal Chemistry Novel Research Strategies of Benzimidazole Derivatives: A Review
Mini-Reviews in Medicinal Chemistry Nicotinamide and its Pharmacological Properties for Clinical Therapy
Drug Design Reviews - Online (Discontinued) Recent Advances in the Development of MMPIs and APNIs Based on the Pyrrolidine Platforms
Mini-Reviews in Medicinal Chemistry Mitochondrial MMP Activation, Dysfunction and Arrhythmogenesis in Hyperhomocysteinemia
Current Vascular Pharmacology A Review of Pharmacological and Phytochemical Studies on Convolvulaceae Species <i>Rivea</i> and <i>Ipomea</i>
Current Traditional Medicine Computer Prediction of Cardiovascular and Hematological Agents by Statistical Learning Methods
Cardiovascular & Hematological Agents in Medicinal Chemistry





