Abstract
Cytochrome c oxidases of prion protein (PrP) gene-deficient (Prnp-/-) and Prnp+/+ mice were examined in vivo and in vitro. Non-invasive near-infrared spectra revealed that oxidation of copper and heme a+a3 in cytochrome c oxidase of Prnp-/- mice was similar to that in Prnp+/+ mice. Biochemical analysis of mitochondrial fractions also supported the results. PrP might not be involved in regulation of cytochrome c oxidase.
Keywords: Prion protein, cytochrome c oxidase, mitochondria, copper
Protein & Peptide Letters
Title: Normal Cytochrome c Oxidase Activity in Prion Protein Gene-Deficient Mice
Volume: 15 Issue: 3
Author(s): Akikazu Sakudo, Yojiro Taniuchi, Takanori Kobayashi, Takashi Onodera and Kazuyoshi Ikuta
Affiliation:
Keywords: Prion protein, cytochrome c oxidase, mitochondria, copper
Abstract: Cytochrome c oxidases of prion protein (PrP) gene-deficient (Prnp-/-) and Prnp+/+ mice were examined in vivo and in vitro. Non-invasive near-infrared spectra revealed that oxidation of copper and heme a+a3 in cytochrome c oxidase of Prnp-/- mice was similar to that in Prnp+/+ mice. Biochemical analysis of mitochondrial fractions also supported the results. PrP might not be involved in regulation of cytochrome c oxidase.
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Cite this article as:
Sakudo Akikazu, Taniuchi Yojiro, Kobayashi Takanori, Onodera Takashi and Ikuta Kazuyoshi, Normal Cytochrome c Oxidase Activity in Prion Protein Gene-Deficient Mice, Protein & Peptide Letters 2008; 15 (3) . https://dx.doi.org/10.2174/092986608783744298
DOI https://dx.doi.org/10.2174/092986608783744298 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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