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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: Novel Aminobenzopentathiepine having In Vivo Anticonvulsant and Anxiolytic Activities

Author(s): Tatyana M. Khomenko, Tatyana G. Tolstikova, Alexey V. Bolkunov, Margarita P. Dolgikh, Alla V. Pavlova, Dina V. Korchagina, Konstantin P. Volcho and Nariman F. Salakhutdinov

Volume 6, Issue 6, 2009

Page: [464 - 467] Pages: 4

DOI: 10.2174/157018009789057544

Price: $65


High anticonvulsive and anxiolytic activities of 8-trifluoromethyl-6-amino-benzopentathiepin 5, which can be synthesized by new simple and effective method, have been found. The transformation of the amino group in compound 5 to the amide group drastically changed the biological activity of the compounds.

Keywords: Substituted benzopentathiepins, Anticonvulsive activity, Anxiolytic activity

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