Abstract
The early detection of many human diseases is crucial if they are to be treated successfully. Therefore, the development of imaging techniques that can facilitate early detection of disease is of high importance. Changes in the levels of enzyme expression are known to occur in many diseases, making their accurate detection at low concentrations an area of considerable active research. Activatable fluorescent probes show immense promise in this area. If properly designed they should exhibit no signal until they interact with their target enzyme, reducing the level of background fluorescence and potentially endowing them with greater sensitivity. The mechanisms of fluorescence changes in activatable probes vary. This review aims to survey the field of activatable probes, focusing on their mechanisms of action as well as illustrating some of the in vitro and in vivo settings in which they have been employed.
Keywords: Enzyme, Probe, Activatable, Optical, Fluorescent, imaging techniques, fluorescence molecular tomography, Beta-Lactamase, Sodium dodecyl sulfate polyacrylamide gel electrophoresis
Call for Papers in Thematic Issues
Advances on New Photochromic Compounds. Synthesis and Applications
Photochromic compounds are materials that can reversibly change color or optical properties when exposed to light, typically ultraviolet (UV) or visible light. This reversible color change is due to a molecular rearrangement or isomerization triggered by light absorption. Advances in this field are focused on synthesizing photochromic compounds with faster ...read more
Biorthogonal Chemistry: A translational Chemical Tool for In Vivo Applications
After the discovery in 1990, bioorthogonal chemistry encompassed a set of diverse, fast-paced selective chemical reactions, facilitating the study of biomolecules under physiological aura without intervening in the biochemical processes. Over the past two decades, significant progress has been witnessed in bioorthogonal reactions such as Staudinger ligation, metal-catalyzed coupling reactions, ...read more
Design and Synthesis of Green Pesticides
The development of new green pesticides is currently one of the hotspots in the field of pesticide research, aiming to develop efficient, environmentally friendly, and safe pesticide products to meet the needs of modern agricultural production. New green pesticides prioritize environmental friendliness and ecological safety. Therefore, during the research and ...read more
Design and Synthesis of Novel Green Pesticides
The increasing need for sustainable agriculture has driven the search for novel, environmentally friendly alternatives to conventional chemical pesticides. This thematic issue explores the design and synthesis of novel green pesticides that are super-efficient, non-toxic and residue-free. Emphasizing the development of bio-based and eco-friendly pesticides, the issue highlights cutting-edge research ...read more
Related Books
Ionic Liquids for Organic Synthesis
Glycals and their Derivatives
2-Deoxy-D-Glucose: Chemistry and Biology
Chiral Ionic Liquids: Applications in Chemistry and Technology
Basics of Organic Chemistry: A Textbook for Undergraduate Students
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
52