Mitochondria as a Therapeutic Target in Alzheimers Disease and Diabetes

Title: Mitochondria as a Therapeutic Target in Alzheimers Disease and Diabetes

Volume: 8 Issue: 6

Author(s): Paula I. Moreira, Sandra M. Cardoso, Claudia M. Pereira, Maria S. Santos and Catarina R. Oliveira

Affiliation:

Keywords: Alzheimer's disease, antioxidants, diabetes, mitochondria, MitoQ, MitoVitE, SS peptides

Abstract: Due to the increasing number of data demonstrating a connection between diabetes and Alzheimers disease (AD), efforts have been developed to elucidate the exact mechanism(s) underlying this connection. Although both disorders possess several overlapping features, mitochondrial dysfunction is one of the most relevant rendering mitochondria an important target of scientific research. This review discusses clinical and biochemical features shared by AD and diabetes, giving special attention to the involvement of mitochondria. The realization that mitochondria are at the intersection of cells life and death has made them a promising target for drug discovery and therapeutic interventions. Here we also discuss in vitro, in vivo and clinical studies that examined the effect of mitochondria-directed therapeutics particularly mitochondrial target antioxidants and Szeto-Schiller peptides.

Cite this article as:

Moreira I. Paula, Cardoso M. Sandra, Pereira M. Claudia, Santos S. Maria and Oliveira R. Catarina, Mitochondria as a Therapeutic Target in Alzheimers Disease and Diabetes, CNS & Neurological Disorders - Drug Targets 2009; 8 (6) . https://dx.doi.org/10.2174/187152709789824651