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CNS & Neurological Disorders - Drug Targets


ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Targeting Interleukin-1β for Pain

Author(s): Sivaram Pillarisetti

Volume 10, Issue 5, 2011

Page: [571 - 575] Pages: 5

DOI: 10.2174/187152711796234998

Price: $65


Interleukin-1β (IL-1β) has been implicated in many inflammatory and autoimmune diseases. Its role in pain, however, is under-appreciated. This may in part be due to the challenges involved in approaching the target from a therapeutic stand point. The scope of this brief review is to understand the direct and indirect roles of IL-1β in contributing to different pain states including inflammatory and neuropathic pain, and discuss approaches to block IL-1β production or IL-1 interactions.

Keywords: Interleukin-1, inflammation, pain, neuropathy, analgesic, hyperalgesia, P2X7, Spinal Nerve Ligation, Complex Regional Pain Syndrome, XOMA

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