Abstract
G-rich nucleic acid oligomers can form G-quadruplexes built by G-tetrads stacked upon each other. The basic building block of the G-quadruplexes is similar, but the formation of different quadruplex structures is highly responsive to the strand stoichiometry, strand orientation, guanine glycosidic torsion angle, connecting loops, and the metal coordination. Because of its structural variations and different functions, G-quadruplex applied in biorecognition events can function as a versatile signaling component. A variety of strategies that incorporate G-quadruplex have also been reported. In this review, we mainly discuss G-quadruplex as signal transducer from the following aspects for biorecognition events: analyte-induced G-quadruplex reconfiguration and fluorescence enhancement of small ligand; analyte-induced G-quadruplex reconstruction and formation of DNAzyme; Stimulus-responsive G-quadruplex refolding and manipulation of electron transfer; Stimulus-responsive G-quadruplex and its combination with nanopore systems; Small ligand-responsive Gquadruplex stabilization for drug screening; Nanomaterial-reponsive G-quadruplex reformation; Target-triggered continuous formation of G-quadruplex by DNA nanomachine. We have comprehensively described the recent progress in our labs and others. Undoubtedly, bioanalytical technology and nanotechnology based on G-quadruplex will continue to grow, leading to develop new diagnostics, therapeutics and drug development.
Keywords: G-quadruplex, drug, biosensor, signal transducer, fluorescence, DNAzyme, electrochemistry, torsion angle, biorecognition, Nanomaterial
Current Pharmaceutical Design
Title:G-Quadruplex as Signal Transducer for Biorecognition Events
Volume: 18 Issue: 14
Author(s): Lei Lv, Zhijun Guo, Jiahai Wang and Erkang Wang
Affiliation:
Keywords: G-quadruplex, drug, biosensor, signal transducer, fluorescence, DNAzyme, electrochemistry, torsion angle, biorecognition, Nanomaterial
Abstract: G-rich nucleic acid oligomers can form G-quadruplexes built by G-tetrads stacked upon each other. The basic building block of the G-quadruplexes is similar, but the formation of different quadruplex structures is highly responsive to the strand stoichiometry, strand orientation, guanine glycosidic torsion angle, connecting loops, and the metal coordination. Because of its structural variations and different functions, G-quadruplex applied in biorecognition events can function as a versatile signaling component. A variety of strategies that incorporate G-quadruplex have also been reported. In this review, we mainly discuss G-quadruplex as signal transducer from the following aspects for biorecognition events: analyte-induced G-quadruplex reconfiguration and fluorescence enhancement of small ligand; analyte-induced G-quadruplex reconstruction and formation of DNAzyme; Stimulus-responsive G-quadruplex refolding and manipulation of electron transfer; Stimulus-responsive G-quadruplex and its combination with nanopore systems; Small ligand-responsive Gquadruplex stabilization for drug screening; Nanomaterial-reponsive G-quadruplex reformation; Target-triggered continuous formation of G-quadruplex by DNA nanomachine. We have comprehensively described the recent progress in our labs and others. Undoubtedly, bioanalytical technology and nanotechnology based on G-quadruplex will continue to grow, leading to develop new diagnostics, therapeutics and drug development.
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Cite this article as:
Lv Lei, Guo Zhijun, Wang Jiahai and Wang Erkang, G-Quadruplex as Signal Transducer for Biorecognition Events, Current Pharmaceutical Design 2012; 18 (14) . https://dx.doi.org/10.2174/138161212799958459
DOI https://dx.doi.org/10.2174/138161212799958459 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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