Acylhydrazide Schiff Bases: DPPH Radical and Superoxide Anion Scavengers

Title:Acylhydrazide Schiff Bases: DPPH Radical and Superoxide Anion Scavengers

Volume: 8 Issue: 4

Author(s): Khalid Mohammed Khan, Muhammad Taha, Farzana Naz, Salman Siddiqui, Sajjad Ali, Fazal Rahim, Shahnaz Perveen and M. Iqbal Choudhary

Affiliation:

Keywords: Acylhyrazide Schiff bases, DPPH scavenger, superoxide anion scavenger, antioxidant, chemotherapeutic agents, antifungal, antiproliferative properties, anticonvulsant, analgesic

Abstract: Acylhydrazide Schiff bases 1-27 were evaluated for their in vitro DPPH radical and superoxide anion scavenging activity. They showed a varying degree of DPPH radical scavenging activity with IC50 values between 31.25 - 473.59 µM. Compounds 8, 2, and 10 have IC50 values 31.25 ± 1.32, 34.40 ± 0.66, and 37.24 ± 0.4 µM, respectively. Standard npropylgallate showed an IC50 value 30.12 ± 0.27 µM. Acylhydrazides 1-27 exhibited in vitro superoxide anion scavenging activities with IC50 values in the range of 175.6 - 450.89 µM. Results demonstrated that acylhyrazides 8, 2, and 10 have DPPH scavenging activity, comparable to standard n-propyl gallate while acylhyrazides 1-27 were found to be less superoxide anion scavenging active than the standard n-propyl gallate (IC50 = 106.34 ± 1.6 µM).

Cite this article as:

Mohammed Khan Khalid, Taha Muhammad, Naz Farzana, Siddiqui Salman, Ali Sajjad, Rahim Fazal, Perveen Shahnaz and Iqbal Choudhary M., Acylhydrazide Schiff Bases: DPPH Radical and Superoxide Anion Scavengers, Medicinal Chemistry 2012; 8 (4) . https://dx.doi.org/10.2174/157340612801216111