Abstract
Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis, phagocytosis or autophagy. In this review, we describe the lipid composition and the dynamic properties of lysosomal membrane, the main delivery pathways of lipids to lysosomes and their catabolism inside lysosomes. Then, we present the consequences of a lipid accumulation as seen in various lysosomal storage diseases on lysosomal functions. Finally, we discuss about the possible involvement of lysosomes in lipotoxicity.
Keywords: Lipids, lysosomes, lysosomal hydrolysis and lysosomal trafficking
Current Drug Metabolism
Title:Lipids and Lysosomes
Volume: 13 Issue: 10
Author(s): Isabelle Hamer, Guillaume Van Beersel, Thierry Arnould and Michel Jadot
Affiliation:
Keywords: Lipids, lysosomes, lysosomal hydrolysis and lysosomal trafficking
Abstract: Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis, phagocytosis or autophagy. In this review, we describe the lipid composition and the dynamic properties of lysosomal membrane, the main delivery pathways of lipids to lysosomes and their catabolism inside lysosomes. Then, we present the consequences of a lipid accumulation as seen in various lysosomal storage diseases on lysosomal functions. Finally, we discuss about the possible involvement of lysosomes in lipotoxicity.
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Cite this article as:
Hamer Isabelle, Van Beersel Guillaume, Arnould Thierry and Jadot Michel, Lipids and Lysosomes, Current Drug Metabolism 2012; 13 (10) . https://dx.doi.org/10.2174/138920012803762684
DOI https://dx.doi.org/10.2174/138920012803762684 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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