Cerebrovascular Damage as a Cause for Alzheimers Disease

Title: Cerebrovascular Damage as a Cause for Alzheimers Disease

Volume: 2 Issue: 4

Author(s): C. Humpel and J. Marksteiner

Affiliation:

Keywords: vascular system, alzheimer, vascular dementia, hypothesis, cascade

Abstract: Alzheimers disease is a progressive brain disorder that gradually destroys a patients memory function and ability to carry out daily activities. According to the prevailing amyloid cascade hypothesis, Alzheimers disease is initiated by amyloid ß-peptide accumulation leading to neuronal toxicity. The neurofibrillary tangle deriving from hyperphosphorylated tau and synapse loss are also key features for Alzheimers disease. Recent studies revealed a significant comorbidity of Alzheimers disease and cerebrovascular disease suggesting that cerebrovascular dysregulation is an important feature of Alzheimers disease. This mini-review will discuss the hypothesis that a dysfunction of the vascular system may result in damage of the neurovascular unit, initiating a cascade of events. An overlap with other forms of cognitive impairment, such as mild cognitive impairment, or vascular dementia will be discussed.

Cite this article as:

Humpel C. and Marksteiner J., Cerebrovascular Damage as a Cause for Alzheimers Disease, Current Neurovascular Research 2005; 2 (4) . https://dx.doi.org/10.2174/156720205774322610