Abstract
High Resolution Magic Angle Spinning (HR-MAS) NMR spectroscopy is a versatile technique that provides high resolution NMR data on samples containing solutions, gels and swellable solids. In addition to providing structural information HR-MAS can also be used to investigate interfaces (for example organic structures at the solid-aqueous soil interface), processes such as swelling/ flocculation, kinetic transfer between gel/liquid phases, as well as conformation and molecular interactions in situ. As such, HRMAS has potential in a diversity of fields including organic, biological, environmental, and medical research. This manuscript focuses on the application of HR-MAS to intact natural samples. A range of 1D and 2D NMR experiments are reviewed and compared in terms of general performance on a range of samples. Therefore, this practical guide and review should be a useful reference and starting point for those wishing to apply HR-MAS NMR. While this article focuses on natural samples, common key 1D and 2D experiments are considered which may be of interest to readers with diverse research interests.
Keywords: 1D NMR, 2D NMR, Algae, High resolution magic angle spinning (HR-MAS), Natural samples, NMR, Soils, Worm tissue.
Call for Papers in Thematic Issues
Advances and Applications of Enantioselective Organic Synthesis.
The development of enantioselective synthetic methodologies remains a cornerstone of modern organic chemistry, enabling the precise construction of chiral molecules with profound impact in pharmaceuticals, agrochemicals, and materials science. This thematic issue, Advances and Applications of Enantioselective Organic Synthesis, highlights recent progress in catalytic strategies, including organocatalysis, metal-based catalysis, and ...read more
Design and Functionalization of Nitrogen-Containing Aromatic Heterocycles: New Synthetic Reactions, Mechanistic Insights, and Spectroscopic Characterization
Nitrogen-containing aromatic heterocycles are key structural motifs in numerous biologically active molecules, and their diverse architectures support a broad spectrum of pharmacological applications. These systems have been extensively explored for their anticancer, antiviral, and antiretroviral activities, with particular promise in anti-HIV research. Beyond medicinal chemistry, their design and functionalization enable ...read more
Emerging Catalytic Strategies in Heterocyclic Chemistry
Heterocyclic chemistry remains at the heart of organic synthesis, with profound applications in pharmaceuticals, agrochemicals, and functional materials. Recent advances in catalysis, including photocatalysis, electrocatalysis, transition-metal catalysis, and nanomaterial-based approaches, are reshaping the synthesis and functionalization of heterocycles. These strategies offer enhanced selectivity, sustainability, and versatility, providing novel pathways for ...read more
Hybrid-Materials Catalyzed Conversion of Molecules and Substances
To address the global energy and environmental issues, and inspired by the photosynthesis of plants, scientists have material shifted their focus from traditional chemistry to novel ones to discover new substances and molecules. Hybrid materials with their unique synergistic effects, interface regulation capabilities, and functional integration have emerged as a ...read more
Related Books
Solid Base Catalysis: A New Frontier in Industrial Sustainability
Ionic Liquids for Organic Synthesis
Glycals and their Derivatives
2-Deoxy-D-Glucose: Chemistry and Biology
Chiral Ionic Liquids: Applications in Chemistry and Technology
Basics of Organic Chemistry: A Textbook for Undergraduate Students
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
167