Abstract
Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages, caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms associated with caveolin-1-dependent tumor suppression will be briefly discussed before focusing on the role of this protein and particularly phosphorylation of tyrosine-14 in promoting cell migration, invasion and metastasis. Models are provided summarizing possible explanations for these dramatic changes in function, as well as mechanisms by which this may be achieved.
Keywords: Cancer progression, Caveolin-1 (CAV1), invasion, metastasis, migration, phosphorylation, tyrosine-14.
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Metabolic reprogramming is a hallmark of numerous diseases, including cancer, metabolic disorders, and neurodegeneration. Understanding the intricate cell signaling pathways, transduction pathways, and omics-based data is important for the development of novel pharmacological interventions. This special issue of Current Molecular Medicine will be devoted to the current advances in drug ...read more
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