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Current Pharmaceutical Analysis


ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

Voltammetric Quantification of Antispasmodic Drug Drotaverine Hydrochloride in Human Serum

Author(s): Rajeev Jain and Nimisha Jadon

Volume 11, Issue 2, 2015

Page: [145 - 154] Pages: 10

DOI: 10.2174/1573412911666141215214105

Price: $65


Drotaverine hydrochloride is an antispasmodic drug used to relieve cramps or spasms of the stomach, intestines and bladder. The electro reductive behaviour of drotaverine has been investigated and one irreversible well-defined cathodic peak was observed at -1.04 V vs. Ag/AgCl ((3.0 M) KCl). A validated, sensitive and reproducible cathodic adsorptive stripping voltammetric procedure for the trace determination of the bulk drug in human serum has been developed. The peak current showed a linear dependence with the drug concentration over the range 50 ng/mL to 25.6 μg/mL for Square-Wave Cathodic Adsorptive Stripping Voltammetry (SWCAdSV) and 0.2 μg/mL to 51.8 μg/mL for Differential Pulse Cathodic Adsorptive Stripping Voltammetry (DPCAdSV). Applicability to assay the drug in serum samples was illustrated and minimum detectability was found to be 49.83 ng/mL.

Keywords: Drotaverine hydrochloride, HMDE, pharmaceutical preparations, human serum, adsorptive stripping voltammetric techniques.

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