Peptide Bacteriocins - Structure Activity Relationships

Title:Peptide Bacteriocins - Structure Activity Relationships

Volume: 16 Issue: 2

Author(s): Hashem Etayash, Sarfuddin Azmi, Ramana Dangeti and Kamaljit Kaur

Affiliation:

Keywords: Bacteriocin analogues, Bacteriocins, Structure-activity relationship.

Abstract: With the growing concerns in the scientific and health communities over increasing levels of antibiotic resistance, antimicrobial peptide bacteriocins have emerged as promising alternatives to conventional small molecule antibiotics. A substantial attention has recently focused on the utilization of bacteriocins in food preservation and health safety. Despite the fact that a large number of bacteriocins have been reported, only a few have been fully characterized and structurally elucidated. Since knowledge of the molecular structure is a key for understanding the mechanism of action and therapeutic effects of peptide, we centered our focus in this review on the structure-activity relationships of bacteriocins with a particular focus in seven bacteriocins, namely, nisin, microcin J25, microcin B17, microcin C, leucocin A, sakacin P, and pediocin PA-1. Significant structural changes responsible for the altered activity of the recent bacteriocin analogues are discussed here.

Cite this article as:

Etayash Hashem, Azmi Sarfuddin, Dangeti Ramana and Kaur Kamaljit, Peptide Bacteriocins - Structure Activity Relationships, Current Topics in Medicinal Chemistry 2016; 16 (2) . https://dx.doi.org/10.2174/1568026615666150812121103