Current Status of Magnetite-Based Core@Shell Structures for Diagnosis and Therapy in Oncology Short running title: Biomedical Applications of Magnetite@Shell Structures

Title:Current Status of Magnetite-Based Core@Shell Structures for Diagnosis and Therapy in Oncology Short running title: Biomedical Applications of Magnetite@Shell Structures

Volume: 21 Issue: 37

Author(s): Ângela Leão Andrade, José Domingos Fabris, Rosana Zacarias Domingues and Márcio C. Pereira

Affiliation:

Keywords: Magnetite, core-shell, magnetic resonance imaging, hyperthermia, drug delivery, specific absorption rate, relaxivity constant, theranostic.

Abstract: Superparamagnetic iron oxides, as magnetite (Fe₃O₄) or maghemite (γ-Fe₂O₃), are primary materials with intrinsic properties that enable them, as single components or as special composites, to base advanced techniques in medical clinical practices, as a contrast agent in magnetic resonance imaging (MRI), as magneticallyinduced hyperthermic heat generator, and as a magnetic guide to locally deliver drugs to specific sites in the human body. An interesting approach to developing nanoplatforms for those applications consists in manufacturing core@shell nanostructures, in which the precursor magnetic iron oxide (usually, magnetite) acts as a core, and an organic, or inorganic compound is used as a shell in a multifunctional composite. In this review, we report the current advances in the use of magnetite-based core@shell nanostructures, including Fe₃O₄@SiO₂ and Fe₃O₄@polymers, in MRI, magnetic hyperthermia and drug delivery systems for diagnosis and therapy of tumor cells. The development of nanoplatforms for combined therapy and diagnostic (theranostic) is also addressed.

Cite this article as:

Andrade Leão Ângela, Fabris Domingos José, Domingues Zacarias Rosana and Pereira C. Márcio, Current Status of Magnetite-Based Core@Shell Structures for Diagnosis and Therapy in Oncology Short running title: Biomedical Applications of Magnetite@Shell Structures, Current Pharmaceutical Design 2015; 21 (37) . https://dx.doi.org/10.2174/1381612821666150917093543