Natural and Synthetic Coumarin Derivatives with Anti-Inflammatory / Antioxidant Activities

Title: Natural and Synthetic Coumarin Derivatives with Anti-Inflammatory / Antioxidant Activities

Volume: 10 Issue: 30

Author(s): Konstantina C. Fylaktakidou, Dimitra J. Hadjipavlou-Litina, Konstantinos E. Litinas and Demetrios N. Nicolaides

Affiliation:

Keywords: natural coumarins, synthetic coumarins, antiinflammatories, antioxidants

Abstract: Several natural products with a coumarinic moiety have been reported to have multiple biological activities. It is to be expected that, in a similar way to isomeric flavonoids, coumarins might affect the formation and scavenging of reactive oxygen species (ROS) and influence processes involving free radical-mediated injury. Coumarin can reduce tissue edema and inflammation. Moreover coumarin and its 7-hydroxy-derivative inhibit prostaglandin biosynthesis, which involves fatty acid hydroperoxy intermediates. Natural products like esculetin, fraxetin, daphnetin and other related coumarin derivatives are recognised as inhibitors not only of the lipoxygenase and cycloxygenase enzymic systems, but also of the neutrophil-dependent superoxide anion generation. Due to the unquestionable importance of coumarin derivatives considerable efforts have been made by several investigators, to prepare new compounds bearing single substituents, or more complicated systems, including heterocyclic rings mainly at 3-, 4- and / or 7-positions. In this review we shall deal with naturally occurring or synthetically derived coumarin derivatives, which possess antiinflammatory as well as antioxidant activities.

Cite this article as:

Fylaktakidou C. Konstantina, Hadjipavlou-Litina J. Dimitra, Litinas E. Konstantinos and Nicolaides N. Demetrios, Natural and Synthetic Coumarin Derivatives with Anti-Inflammatory / Antioxidant Activities, Current Pharmaceutical Design 2004; 10 (30) . https://dx.doi.org/10.2174/1381612043382710