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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Metal Ions and Metal Complexes in Alzheimer’s Disease

Author(s): Angelo Spinello, Riccardo Bonsignore, Giampaolo Barone, Bernhard K. Keppler and Alessio Terenzi

Volume 22, Issue 26, 2016

Page: [3996 - 4010] Pages: 15

DOI: 10.2174/1381612822666160520115248

Price: $65


Background: Alzheimer’s disease (AD) is the most common form of dementia that seriously affects daily life. Even if AD pathogenesis is still subject of debate, it is generally accepted that cerebral cortex plaques formed by aggregated amyloid-β (Aβ) peptides can be considered a characteristic pathological hallmark. It is well known that metal ions play an important role in the aggregation process of Aβ. Methods: This review focuses on the anti-Aβ aggregation activity of chelating ligands as well as on the use of metal complexes as diagnostic probes and as potential drugs. Conclusion: While chelating agents, such as curcumin or flavonoid derivatives, are currently used to capture metal ions responsible for Aβ aggregation, the potential application of platinum, ruthenium and cobalt complexes, among others, of several heterocyclic ligands, represents a promising new strategy to fight AD.

Keywords: Alzheimer’s Disease, metal ions, metal complexes, AD drugs, anti-Aβ aggregating agents, imaging.

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