Abstract
This review focuses on the fast testosterone actions on the cell membrane principally on the Sertoli cells, its predominant effect, i.e. an increase in [Ca2+]i and the possibility of its actions being mediated by KIR (ATP) channels. The regulation of the K+ ATP channels by phosphatidylinositol-4,5-bisphosphate depletion on the cell membrane as a result of the action of testosterone, its putative receptors, and the phospholipase C - phosphatidylinositol-4,5-bisphosphate pathway are discussed. The electrostatic interaction between anionic and cationic charges on the K+ ATP modulation is also considered, in the light of testosterones effect on phospholipase C - phosphatidylinositol-4,5-bisphosphate hydrolysis. Thus, the interaction of testosterone with its putative receptors, phospholipase C, phosphatidylinositol-4,5-bisphosphate, and K+ ATP channels (or other KIR channels) in the membrane may be one of the mechanism of rapid testosterones physiological action on some classes of cells.
Keywords: atp channels, testosterone, sertoli cell, sulphonylureas, diazoxide, phospholipase c, phospholipids, intracellular calcium
Current Pharmaceutical Design
Title: Testosterone Action on the Sertoli Cell Membrane: A KIR6.x Channel Related Effect
Volume: 10 Issue: 21
Author(s): Wassermann G. F. and Loss E. S.
Affiliation:
Keywords: atp channels, testosterone, sertoli cell, sulphonylureas, diazoxide, phospholipase c, phospholipids, intracellular calcium
Abstract: This review focuses on the fast testosterone actions on the cell membrane principally on the Sertoli cells, its predominant effect, i.e. an increase in [Ca2+]i and the possibility of its actions being mediated by KIR (ATP) channels. The regulation of the K+ ATP channels by phosphatidylinositol-4,5-bisphosphate depletion on the cell membrane as a result of the action of testosterone, its putative receptors, and the phospholipase C - phosphatidylinositol-4,5-bisphosphate pathway are discussed. The electrostatic interaction between anionic and cationic charges on the K+ ATP modulation is also considered, in the light of testosterones effect on phospholipase C - phosphatidylinositol-4,5-bisphosphate hydrolysis. Thus, the interaction of testosterone with its putative receptors, phospholipase C, phosphatidylinositol-4,5-bisphosphate, and K+ ATP channels (or other KIR channels) in the membrane may be one of the mechanism of rapid testosterones physiological action on some classes of cells.
Export Options
About this article
Cite this article as:
F. G. Wassermann and S. E. Loss, Testosterone Action on the Sertoli Cell Membrane: A KIR6.x Channel Related Effect, Current Pharmaceutical Design 2004; 10 (21) . https://dx.doi.org/10.2174/1381612043383809
DOI https://dx.doi.org/10.2174/1381612043383809 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
Advances in the Molecular Pathogenesis of Inflammatory Bowel Disease.
This thematic issue will emphasize the recent breakthroughs in the mechanisms of Inflammatory bowel disease (IBD) pathogenesis and devotes some understanding of both Crohn’s and ulcerative colitis. It is expected to include studies about cellular and genetic aspects, which help to precipitate the disease, and the immune system-gut microbiome relations ...read more
Blood-based biomarkers in large-scale screening for neurodegenerative diseases
Disease biomarkers are necessary tools that can be employed in several clinical context of use (COU), ranging from the (early) diagnosis, prognosis, and prediction, to monitoring of disease state and/or drug efficacy. Regarding neurodegenerative diseases, in particular Alzheimer’s disease (AD), a battery of well-validated biomarkers are available, such as cerebrospinal ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Diabetes mellitus: advances in diagnosis and treatment driving by precision medicine
Diabetes mellitus (DM) is a chronic degenerative metabolic disease with ever increasing prevalence worldwide which is now an epidemic disease affecting 500 million people worldwide. Insufficient insulin secretion from pancreatic β cells unable to maintain blood glucose homeostasis is the main feature of this disease. Multifactorial and complex nature of ...read more

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Effect in Topical Use of Lycogen<sup>TM</sup> via Sonophoresis for Anti-aging on Facial Skin
Current Pharmaceutical Biotechnology Editorial [Special Board Members Issue}
Anti-Cancer Agents in Medicinal Chemistry Synthesis and Antiproliferative Activity of Substituted 3[2-(1H-indol-3-yl)- 1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, Marine Alkaloid Nortopsentin Analogues
Current Medicinal Chemistry Curcumin: A Natural Pan-HDAC Inhibitor in Cancer
Current Pharmaceutical Design Gold Nanorods are Selective Cytotoxic Agents
Anti-Cancer Agents in Medicinal Chemistry LRP/LR as an Alternative Promising Target in Therapy of Prion Diseases, Alzheimers Disease and Cancer
Infectious Disorders - Drug Targets Combinations of Plant Polyphenols & Anti-Cancer Molecules: A Novel Treatment Strategy for Cancer Chemotherapy
Anti-Cancer Agents in Medicinal Chemistry Jaboticaba Peel Extract Exerts Chemopreventive Effects in Transgenic Mouse Model of Prostate Cancer
The Natural Products Journal Flavonoids as Prospective Aromatase Inhibitors in Breast Cancer Prevention/ Therapy
Current Molecular Pharmacology Proteasome Inhibitors: Recent Advances and New Perspectives In Medicinal Chemistry
Current Topics in Medicinal Chemistry Exploration of the Medicinal Peptide Space
Protein & Peptide Letters Current Status of Epigenetics and Anticancer Drug Discovery
Anti-Cancer Agents in Medicinal Chemistry Anticancer Antioxidant Regulatory Functions of Phytochemicals
Current Medicinal Chemistry Research Progress in Predicting DNA Methylation Modifications and the Relation with Human Diseases
Current Medicinal Chemistry Tanshinone IIA: Pharmacology, Total Synthesis, and Progress in Structure-modifications
Current Medicinal Chemistry Current Strategies for Probing Substrate Specificity of Proteases
Current Medicinal Chemistry Thymoquinone: Major Molecular Targets, Prominent Pharmacological Actions and Drug Delivery Concerns
Current Bioactive Compounds Drug Target Identification for Neuronal Apoptosis Through a Genome Scale Screening
Current Medicinal Chemistry Cancer Therapeutics: Emerging Targets and Trends
Current Cancer Therapy Reviews Retroviral Gene Therapy: Safety Issues and Possible Solutions
Current Gene Therapy