Abstract
Background: The genus Piper L. has the shikimic acid pathway predominantly expressed, biosynthesizing many cinnamic acid derivatives (CAD).
Objective: Neolignans comprise an important class of CAD that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, insecticidal, anti-inflammatory, antioxidant, smooth muscle relaxant, neuroprotective, antiprotozoal and against platelet aggregation factor. These substances have been extracted and isolated from Piper species using different technics. Results: The present review aims to summarize extraction and isolation methods and biological activities of the different types of neolignans covering the period from 1968 to January 2016.Keywords: Biological activity, extraction, isolation, natural products, neolignans, Piper, Piperaceae.
Mini-Reviews in Medicinal Chemistry
Title:An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities
Volume: 17 Issue: 8
Author(s): Arthur Ladeira Macedo, Thais Carvalho Costa dos Santos, Alessandra Leda Valverde, Davyson de Lima Moreira and Thatyana Rocha Alves Vasconcelos*
Affiliation:
- Departmento de Quimica Organica, Instituto de Quimica, Universidade Federal Fluminense, CEP: 24020-141, Niteroi,Brazil
Keywords: Biological activity, extraction, isolation, natural products, neolignans, Piper, Piperaceae.
Abstract: Background: The genus Piper L. has the shikimic acid pathway predominantly expressed, biosynthesizing many cinnamic acid derivatives (CAD).
Objective: Neolignans comprise an important class of CAD that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, insecticidal, anti-inflammatory, antioxidant, smooth muscle relaxant, neuroprotective, antiprotozoal and against platelet aggregation factor. These substances have been extracted and isolated from Piper species using different technics. Results: The present review aims to summarize extraction and isolation methods and biological activities of the different types of neolignans covering the period from 1968 to January 2016.Export Options
About this article
Cite this article as:
Macedo Ladeira Arthur, dos Santos Carvalho Costa Thais, Valverde Leda Alessandra, Moreira de Lima Davyson and Vasconcelos Rocha Alves Thatyana*, An Overview of Neolignans of the Genus Piper L.: Isolation Methods and Biological Activities, Mini-Reviews in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1389557516666161130094826
DOI https://dx.doi.org/10.2174/1389557516666161130094826 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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