Abstract
Background: The principal aim of this study was to investigate the oxidative effects of acute alcohol consumption on the functions of the heart and the liver and the possible modification of this effect by phenolic compounds from n-butanol extract of Camellia sinensis supplementation.
Method: Three experimental groups of rats were used: control, ethanol-exposed (40% v/v, 5 g/kg per oral every 12 hours for 3 doses, binge model), and ethanol-exposed plus n-butanol extract of Camellia sinensis (100 mg/kg once a day for three days before and simultaneously with ethanol administration). Serum transaminases, cholesterol, triglycerides, lipid peroxidation (MDA), reduced glutathione (GSH) and glutathione peroxidase (GPx) were estimated to assess organs damage. Results: n-butanol extract of Camellia sinensis at a dose of 100 mg/kg body weight exhibited a significant reversal effect in all biochemical parameters measured such as extent of lipid peroxidation, GSH, lipid profile, and serum aminotransferase activities. Conclusion: These results suggest that n-butanol extract of Camellia sinensis protected the heart and the liver from binge ethanol induced injury through attenuating oxidative stress.Keywords: Alcohol, hepatotoxicity, cardiotoxicity, Camellia sinensis, oxidative stress, antioxidant.
Graphical Abstract
Call for Papers in Thematic Issues
Innovative Approaches for Monitoring Cardiological and Hematological Patients
In recent years, the scientific community has become particularly interested in the frontier areas of medical science: telemedicine, big data, artificial intelligence, and biomarkers. At the same time, an interdisciplinary approach in cardiology and hematology is of great importance, given the increasing importance of multimorbidity with the advent of new ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Bioactive Compounds
Current Cancer Drug Targets
Combinatorial Chemistry & High Throughput Screening
Current Cancer Therapy Reviews
Current Diabetes Reviews
Current Drug Safety
Current Drug Targets
Current Drug Therapy
Related Books
The Role of Nutraceuticals in Degenerative Diseases (Part 2)
Herb-Drug Interactions: A Medicinal Approach
The Role of Nutraceuticals in Degenerative Diseases (Part 1)
Brain Tumor Drug Development: Current Advances and Strategies (Part 2)
The Role of Asymmetric Synthesis in Drug Discovery
Brain Tumor Drug Development: Current Advances and Strategies (Part 1)
Handbook of Practical Pharmacology - I
Drug Repurposing for Antivirals
New Drugs Targeting Antibiotic-Resistant Bacteria: Recent Advances
Technical Advances in Pharmacy: An Overview
41
4