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Current Cancer Drug Targets


ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Review Article

Mutational Testing in Gastrointestinal Stromal Tumor

Author(s): Yu Wang* and Jerry Call

Volume 19, Issue 9, 2019

Page: [688 - 697] Pages: 10

DOI: 10.2174/1568009619666190326123945

Price: $65


Targeted treatment has become a major modality in cancer management. Such cancer drugs are generally designed to treat tumors with certain genetic/genomic makeups. Mutational testing prior to prescribing targeted therapy is crucial in identifying who can receive clinical benefit from specific cancer drugs. Over the last two decades, gastrointestinal stromal tumors (GISTs) have evolved from histogenetically obscure to being identified as distinct gastrointestinal mesenchymal tumors with well-defined clinical and molecular characteristics, for which multiple lines of targeted therapies are available. Although the National Comprehensive Cancer Network (NCCN) strongly recommends mutational testing for optimal management of GIST, many GIST patients still have neither a mutation test performed or any mutation-guided cancer management. Here, we review the mutation-guided landscape of GIST, mutational testing methods, and the recent development of new therapies targeting GIST with specific mutations.

Keywords: Gastrointestinal stromal tumor, sarcoma, mutational testing, KIT, PDGFRA, mutation-guided cancer management.

Graphical Abstract
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