Frontiers In Medicinal Chemistry

Harnessing the Neurological Properties of Indian Brain Health Booster Brahmi

Author(s): Neerja Tiwari, Manju Singh, Namita Gupta, Kishan Singh and Kapil Dev * .

Pp: 179-204 (26)

DOI: 10.2174/9789815165043123100008

* (Excluding Mailing and Handling)


Brahmi (Bacopa monnieri Linn.) is a well-known therapeutic herb used in a broad spectrum of conventional medicines to alleviate various ailments, prominently those involving intellect, anxiety and mental health. In Ayurveda, it is classified as Medhya rasayanas (meaning intellect rejuvenator) and claimed to be a cognitive nutrient and memory enhancer. Although the plant possesses a plethora of compounds, its neurological activity is mainly attributed to its major phytochemical constituents, i.e., bacoside saponins. Majorly isolated compounds are dammarane triterpenoids glycone and aglycones. There are several reports published with neurological activities on Bacopa monnieri to validate traditional claims through scientific findings. Some therapeutic formulations containing standardized extracts of Bacopa monnieri have also been developed for the betterment of mental health. Besides, being neuroprotective, the plant is reported to possess anti-inflammatory, analgesic, and antipyretic properties and systemic disorders like cardiovascular, hepatic, gastrointestinal, myocardial ischemia, respiratory problems, opioid-related nephrotoxicity and hepatotoxicity. The present chapter described the phytochemical profiling, extraction and isolation, neurological properties, as well as toxicological and clinical studies of the plant. 

Keywords: Bacopa monnieri, Bacoside, Brahmi, Dammarane triterpenes, Neurological disorders, Neurodegenerative disease.

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