Frontiers In Medicinal Chemistry

Shikonin, a Naphthaquinone of Commercial Importance: its Biosynthesis and Prospect for Use as Drugs

Author(s): Ravi S. Singh* and Sanjay Kumar

Pp: 233-248 (16)

DOI: 10.2174/9789815165043123100011

* (Excluding Mailing and Handling)


Shikonin is a red naphthaquinone pigment present in the roots of plants of the Boraginaceae family. This pigment is an as active ingredient in several pharmaceutical and cosmetics preparations, and as a dye for fabrics and food items. It shows many bioactivities such as stimulation of peroxidase, protection against UV-radiation, inhibition of microsomal monooxygenase and induction and secretion of nerve growth factor. In this book chapter, we have provided detailed information on its biosynthesis and prospects for pharmaceutical use.

Keywords: Biosynthesis, Naphthaquinone, Secondary metabolites, Shikonin.

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