Frontiers In Medicinal Chemistry

Implications of DNA-acting Agents as Anticarcinogenic Potential in Breast Cancer Therapeutics

Author(s): Lovely Sinha* and Ujjwal Kumar

Pp: 262-280 (19)

DOI: 10.2174/9789815165043123100013

* (Excluding Mailing and Handling)


Breast cancer is the most prevalent neoplasm diagnosed in women worldwide. There are many factors responsible for breast cancer susceptibility. Mutation in tumor suppressor genes BRCA1 and BRCA2 predispose women to the early onset of breast cancer. The BRCA genes are involved in multiple cellular processes in response to DNA damage, including checkpoint activation, gene transcription, and DNA repair. Several DNA-acting agents act as effective anticancer used for treating cancer disease. Certain groups of chemicals are known to affect specific phases of cell division, such as, Cyclophosphamide is the most potent and successful anticancer agent that acts by alkylating the N-7position of guanine to cause crosslinking of DNA’s double helix, resulting in DNA breaks that interfere with the DNA replication and RNA transcription. This chapter deals with the classification of DNA-acting agents according to their modes of action.

Keywords: Breast Cancer, Cyclophosphamide, DNA-acting agent, DNA damage.

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