Waste Clearance in the Brain

Phagocytosis and Scavenger Receptors in the Brain

Author(s): Gaiqing Wang*, Haiyun Chen, Juan Yang, Jing Wang, Bo Yan and Minglei Chen

Pp: 80-89 (10)

DOI: 10.2174/9789815313086124010012

Abstract

Phagocytosis is a vital process where immune cells called phagocytes engulf and digest foreign particles, pathogens, and cellular debris. This process is crucial for tissue homeostasis and infection defense. Scavenger receptors, found on immune cells like microglia, recognize and bind to diverse ligands such as pathogens, altered self-molecules, and cellular debris. They are pivotal in facilitating phagocytosis and clearing these substances from the body.


Keywords: CD36/CD47/CD163, Low-density lipoprotein receptor-related protein-1(LRP1), Microglia, Macrophages, Scavenger receptors.

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