Recent Advances in the Synthesis of O- and S-Glycosides from Glycals

Pp: 24-68 (45)

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Abstract

Approximately 20 to 30 percent of all natural drugs are glycosylated, and the attached carbohydrate unit is pivotal for their biological activity. O- and S-glycosides constitute a significant portion of various biologically potent molecules and natural products. The synthesis of O- and S-glycosides holds immense importance due to several medicinal benefits. This chapter explores several methodologies for accessing O- and S-glycosides and the subsequent utilization of these glycosides for oligosaccharide generation. Specific pathways involved in O- and S-glycosides synthesis are discussed, along with detailed consideration of factors influencing the stereoselectivity of the desired products.

Keywords: Acceptors, Glycosyl donors, Glycals, Oligosaccharides, O-glycosides, S-glycosides, Stereoisomers.

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