Total Synthesis of Natural Products and Medicinally Important Molecules from Glycals

Abstract

Glycals have been widely used as a versatile building block for the synthesis of C-glycosides and branched sugars and the total synthesis of natural products and biologically active molecules. The versatility of glycals is due to their easy availability and the presence of a ring oxygen connected to a double bond. The inherent chirality of glycals also makes them valuable for the synthesis of various natural products and pharmaceuticals. This chapter provides a detailed overview of the progress made in synthesizing natural products and important molecules derived from glycals.

Keywords: Bradyrhizose, Carbohydrates, Catalysis, Cycloaddition, Drugs, Diospongin, Epoxide, Glycals, Glycosides, Glucopyranoside, Hemicetal, Natural products, Reblastatin, Synthon, Stereoselectivity, Total synthesis, Tricyclic flavonoid, Takai olefination, Yamaguchi esterification, α, β-unsaturated ketones.