<![CDATA[Current Green Chemistry (Volume 11 - Issue 3)]]> https://eurekaselect.com/journal/141 RSS Feed for Journals | BenthamScience EurekaSelect (+https://eurekaselect.com) 2024-03-22 <![CDATA[Current Green Chemistry (Volume 11 - Issue 3)]]> https://eurekaselect.com/journal/141 <![CDATA[Eco-friendly Synthesis of Indole Conjugated Chromeno[d]Pyrimidines as Anti-cancer Agents and their Molecular Modelling Studies]]>https://eurekaselect.com/article/1354372024-03-22Introduction: Many medicinally active new chemical entities depend on indole conjugated chromeno[d]pyrimidine derivatives as a building block. The synthesis of 4-(1H-indol-3-yl)-3,4- dihydro-1H-chromeno[4,3-d]pyrimidine-2,5-dione 4 were achieved in the current study by treating 4- hydroxy-2H-chromen-2-one 1, indole aldehydes 2, and urea/thiourea 3 in the presence of L-proline.

Methods: By adopting the above protocol, we were able to synthesize eight compounds, i.e. 4-(1Hindol- 3-yl)-3,4-dihydro-1H-chromeno[4,3-d]pyrimidine-2,5-diones (4a-4h), in the presence of Lproline as a catalyst in ethanol as solvent for 2-3 hours at 70-75°C with decent yields of 80-85%, and their structures were ascertained by various spectral techniques. They were further screened for their potentiality to inhibit cancer growth in HepG2 and MDA-MD-231 cells.

Results: The scope of the synthesis of biological relevant Indole conjugated Chromeno[ d]Pyrimidines by three-component reaction (MCRs) process was investigated. The most optimised conditions obtained were 0.3 eq of L-proline for 2 hours at 70-75°C which gave the best yield (85%). The few advantages of this newly developed method are excellent yields, no metal catalyst, less toxic solvents, simple workup no chromatographic column purifications. On further screening for their anticancer activities, out of all, the compound 4b displayed noteworthy cytotoxicity with IC50 values of 8.1 and 9.2 μM against HepG2 and MDA-MD-231, respectively. Additionally, in silico studies also supported that compound 4b had favourable binding energy (-7.8 kcal/mol) when compared to the co-crystal ligand (LS5) in inhibiting the human cyclin-dependent kinase 2 (CDK2) protein.

Conclusion: In conclusion, we have developed a simple, convenient, and efficient method for the synthesis of structurally diverse indole conjugated chromeno[d]pyrimidine analogues in the presence of L-proline as catalyst in ethanol as solvent with good yields. Further, the in vitro cytotoxic studies against HepG2 and MDA-MD-231 cells demonstrated that the synthesized compounds had good to reasonable activity, except for compound 4d.

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<![CDATA[Vapor-Liquid Equilibrium of System Comprising Green Solvents: A Holistic Review]]>https://eurekaselect.com/article/1364572024-03-22 <![CDATA[Present State in the Development of Aerogel and Xerogel and their Applications for Wastewater Treatment: A Review]]>https://eurekaselect.com/article/1373342024-03-22 <![CDATA[Novel Aspects and Directions in Pest Control and Management - Proteins with Insecticidal Properties]]>https://eurekaselect.com/article/1372942024-03-22 <![CDATA[Eco-friendly Synthesis of Copper Nanoparticles: An Overview of the Epoch-making Role of Natural Resources, Applications, and Recent Developments]]>https://eurekaselect.com/article/1360462024-03-22 <![CDATA[Biochar Amendment and its Impacts on Medicinal and Aromatic Plants in Sustainable Agriculture]]>https://eurekaselect.com/article/1382222024-03-22Introduction: Biochar application and research have experienced a significant increase in recent decades. It can produce different kinds of organic materials, and it can be employed for different purposes, such as soil conditioning, carbon sequestration and filtration of pollutants from gas and aqueous media. Biochar is a C-rich material, which can be obtained from different types of organic feedstock, such as animal manure, sewage sludge, wood and crop residues and other organic waste. It is also considered an environmentally friendly and resource-saving approach in medicinal and aromatic plants production. Biochar can lead to plant growth improvement and influence on chemical components of medicinal plants, stimulate the growth of soil microflora, increase soil carbonsequestration, bioremediation of soil, regulate carbon fluxes between atmosphere and biosphere, reduce biotic stress in plants, improve soil nutrient availability, decrease abiotic stress in plants, wastewater treatment, immobilization and sorption of soil heavy metal contaminants.

Methods: Relevant literature has been obtained using the keywords “biochar”, “organic amendment”, “soil quality”, “medicinal Plants”, “natural products”, “soil quality”, “macronutrient”, and “chemical components” in scientific databases, such as “PubMed”, “SciFinder”, “Elsevier”, and “Web of Science”.

Results: The aim of this literature review is to study the impact of different kinds of biochars on medicinal and aromatic plants, soil quality and soil fertility by considering case studies of successful paradigms.

Conclusion: Conclusively, we consider our review article will provide an appropriate guide for practitioners and researchers for future studies as well as large-scale field applications.

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