<![CDATA[The International Journal of Gastroenterology and Hepatology Diseases (Volume 2 - Issue 1)]]> https://eurekaselect.com/journal/198 RSS Feed for Journals | BenthamScience EurekaSelect (+https://eurekaselect.com) 2024-01-12 <![CDATA[The International Journal of Gastroenterology and Hepatology Diseases (Volume 2 - Issue 1)]]> https://eurekaselect.com/journal/198 <![CDATA[Brunner's Gland Hamartoma Masquerades as a Neoplastic Mass – A Case Report]]>https://eurekaselect.com/article/1295132024-01-12Background: Brunner's gland proliferation can mimic malignancy; the preoperative diagnosis of this lesion is challenging, and it is accidentally identified during imaging. Most of these lesions are identified as gastrointestinal stromal tumour or malignant tumour. The diagnosis of these lesions requires a histopathological examination.

Case Presentation: Herein, we present a case of Brunner's gland hyperplasia/hamartoma, which was identified as a gastrointestinal stromal tumour at radiography and as submucosal thickening in endoscopy during the routine workup of anemia. However, histopathological examination revealed it to be a Brunner's gland hyperplasia/hamartoma.

Conclusion: A preoperative diagnosis is challenging, so Brunner's gland hyperplasia/hamartoma should be considered as a differential diagnosis. The patient was found to be doing well on followup.

]]>
<![CDATA[Case Report: A Migrating Stitch in a Crohn’s Disease Patient]]>https://eurekaselect.com/article/1297902024-01-12Background: More than half of Crohn’s disease (CD) patients undergo one or more surgical interventions during their lifetime. The main surgical indications for CD are fistulas and stenosis and other emergency conditions such as megacolon and perforation. The risk of CD recurrence at the surgery site is high.

Case Presentation: Here, we report the case of a migrating suture stitch that moved from the abdomen to the subcutaneous tissue of the thigh in a CD patient having undergone intestinal surgery years before.

Results: To the best of our knowledge, there are no previously reported cases of migrating stitches, especially in CD. However, CD is a disease at high risk of surgery due to its clinical characteristics and complications.

Conclusion: In the most doubtful cases, it is advisable to co-operate in a multidisciplinary perspective to provide the patient with the best management.

]]>
<![CDATA[Protective Effects of Ornithine on Hepatic Ischemia-reperfusion Injury]]>https://eurekaselect.com/article/1307932024-01-12 <![CDATA[Identification of Competing Endogenous RNA Networks and Potential Therapeutic Drugs for Gastroesophageal Reflux Disease]]>https://eurekaselect.com/article/1310182024-01-12Background: The diagnosis and cure rate of gastroesophageal reflux disease (GERD) is low, and its pathogenesis remains unclear.

Aims: In this study, we aimed to construct the competing endogenous RNA (ceRNA) of GERD by bioinformatics and explore the potential therapeutic drugs for GERD.

Methods: The differentially expressed genes (DEGs) were got by limma package and visualized by ggplot2 and pheatmap package in R version 4.1.3 from the GSE63401 gene microarray data. The protein- protein interaction (PPI) network was constructed by the STRING database. The hub genes and subnetwork modules were obtained by Cytoscape software. The microRNA and lncRNA were predicted by the miRTarBase and miRNet databases to construct the ceRNA network. Potential drugs targeting DEGs were screened by the CMAP database.

Results: In this study, a total of 571 GEDs were obtained, including 462 up-regulated genes and 109 down-regulated genes, which mainly participated in the leukocyte migration process and the cytokinecytokine receptor interaction pathway. Seventeen miRNAs and three key lncRNAs involved in regulating hub genes were screened through miRTarBase and miRNet databases. Finally, nine ceRNA networks were obtained, including TTN-AS1/NEAT1/XIST - miR-139-5p - CXCR4 axis, TTNAS1/ NEAT1/XIST - miR-185-5p - IL1B axis and TTN-AS1/NEAT1/XIST - miR-495-3p - LYN axis. In addition, five potential drugs (Pimavanserin, BMS-182874, CL-218872, Losartan, and Laropiprant) for GERD were obtained through the CMAP database.

Conclusion: We constructed nine GERD-related ceRNA networks and screened five potential therapeutic drugs for GERD, providing a theoretical basis for further research on the pathogenesis of GERD.

]]>
<![CDATA[The Efficacy of Current Medications and Biomarkers in Hepatic Ischemia- Reperfusion Damage]]>https://eurekaselect.com/article/1310262024-01-122+ overload, oxidative stress and ROS production, and chemokines as well as cytokines generation. Most of the cytokines are generated by helper T cells and neutrophils. A target of Matrix Metalloproteinases (MMPs) in chronic and acute liver injury caused by ischemia can be a significant facilitator of early leukocyte recruitment. Neutrophil gelatinase-associated lipocalin (NGAL) and MMPs could be employed as indicators of the severity of ischemia-reperfusion (I-R) injuries. This review examines the relationship between the components of hepatic IRI, MMPs, and the available pharmaceutical treatments for this condition.]]> <![CDATA[Low Testosterone Levels Predict Sarcopenia Showing an Effect on Prognosis in Patients with Cirrhosis: A Retrospective Study]]>https://eurekaselect.com/article/1316432024-01-12Background: Sarcopenia and low serum testosterone levels are both associated with increased mortality in patients with advanced liver disease. Sarcopenia is a major stumbling block of liver cirrhosis and adversely affects other outcome variables.

Objective: The aim of this study is to compare testosterone levels between sarcopenia and nonsarcopenia cirrhosis patients, to compare serum testosterone levels with cirrhosis severity (Child- Pugh Score), evaluate the correlation between serum testosterone levels and L3 SMI Index (Sarcopenia), the correlation between serum testosterone levels with other prognostic markers of cirrhosis (MELD score).

Method: An observational study of 131 prospectively collected liver cirrhosis patients, who met the inclusion and exclusion criteria, was conducted in the Department of Gastroenterology, National Institute of Medical Sciences and Research, NIMS University, Jaipur, Rajasthan, India, between August 2019 and July 2021. Spearman’s correlation coefficient was used to evaluate the correlation between testosterone levels and L3 SMI.

Results: The mean testosterone level in sarcopenia patients was significantly lowered compared to non-sarcopenia patients (152.05 ± 90.48 vs. 364.28 ± 73.55; p = 0.05). The mean testosterone level was highest in Child A than in Child B and lowest in Child C, which was statistically significant (383.50 ± 54.41 vs. 225.06 ± 58.43 vs. 83.38 ± 25.49, p = 0.05). There was a significantly positive correlation between serum testosterone levels and L3 SMI index by MRI (r = 0.619 and p-value <0.000). There was a significant negative correlation between the MELD score and serum testosterone levels.

Conclusion: Serum testosterone levels were significantly lower in sarcopenic as compared to nonsarcopenic patients. Serum testosterone levels progressively decreased as liver disease severity increased. There was a significant positive correlation between serum testosterone levels and L3- SMI Index (Sarcopenia).

]]>
<![CDATA[Esophageal Foreign Body Removal by Bile Duct Stone Removal Baskets (Litho crush): Think out of the Box; A Case Report]]>https://eurekaselect.com/article/1325322024-01-12