Search Result "pharmacokinetics"


Rapid Determination of Pharmacokinetic Properties of New Chemical Entities: In vivo Approaches

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 5 Issue: 1 Year: 2002 Page: 29-37
Author(s): Kathleen A. Cox, Ronald E. White, Walter A. Korfmacher

Improvement of “Hit-to-Lead” Optimization by Integration of in Vitro HTS Experimental Models for Early Determination of Pharmacokinetic Properties

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 5 Issue: 6 Year: 2002 Page: 459-472
Author(s): Ilona Kariv, Robyn A. Rourick, Daniel B. Kassel, Thomas D.Y. Chung

Organ Perfusion and Mass Spectrometry: A Timely Merger for Drug Development

Journal: Current Topics in Medicinal Chemistry
Volume: 2 Issue: 1 Year: 2002 Page: 77-86
Author(s): C. Gerald Curtis, Ben Chien, David Bar-Or, Kumar Ramu

Current Status of Oral Carbapenem Development

Journal: Current Medicinal Chemistry - Anti-Infective Agents
Volume: 1 Issue: 1 Year: 2002 Page: 1-14
Author(s): Toshio Kumagai, Satoshi Tamai, Takao Abe, Muneo Hikda

N7-Substituted-5-aryl-pyrrolo[2,3-d]pyrimidines Represent a Versatile Class of Potent Inhibitors of the Tyrosine Kinase c-Src

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 2 Issue: 3 Year: 2002 Page: 201-208
Author(s): Eva Altmann, Leo Widler, Martin Missbach

Evaluation of Drug Interactions with P-Glycoprotein in Drug Discovery: In Vitro Assessment of the Potential for Drug-Drug Interactions with P-Glycoprotein

Journal: Current Drug Metabolism
Volume: 3 Issue: 3 Year: 2002 Page: 257-273
Author(s): Jerome H. Hochman, Masayo Yamazaki, Tomoyuki Ohe, Jiunn H. Lin

Whole-Body Autoradiography In Drug Discovery

Journal: Current Drug Metabolism
Volume: 3 Issue: 5 Year: 2002 Page: 451-462
Author(s): E. G. Solon, S. K. Balani, F. W. Lee

Heterocyclic Nucleosides. Chemical Synthesis and Biological Properties

Journal: Current Medicinal Chemistry - Anti-Infective Agents
Volume: 1 Issue: 4 Year: 2002 Page: 389-411
Author(s): Pedro Merino

Utility of NMR in Lead Optimization: Fragment-Based Approaches

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 5 Issue: 8 Year: 2002 Page: 631-643
Author(s): Jeffrey R. Huth, Chaohong Sun

BAY 43-9006: Early Clinical Data in Patients with Advanced Solid Malignancies

Journal: Current Pharmaceutical Design
Volume: 8 Issue: 2 Year: 2002 Page: 2249-2253
Author(s): Sebastien J. Hotte, Hal W. Hirte

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