Abstract
Growth factors are proteins capable of stimulating cell growth, proliferation and differentiation. The Fibroblast Growth Factor (FGF) family is one of the largest growth factor families, comprising of a group of structurally & functionally related family of 22 polypeptide growth factors. FGFs play their physiological roles by binding to the high affinity FGF receptors (FGFRs) expressed on the surface of the target cells. These proteins are the key players in the cell growth, differentiation, migration, morphogenesis, embryonic development, wound healing, tumor growth etc. There are also reports on the involvement of FGFs in certain diseases. However FGFs have also been shown to have immense potential for use in therapeutics. This review is an attempt to provide an insight to the FGFs, their structural and functional aspects, key biological functions along with a brief account of their implication in diseases and therapeutic uses.
Keywords: Growth factors, cell surface receptors, cell differentiation, apoptosis, disease, mutations.
Current Proteomics
Title:An Overview on Fibroblast Growth Factors: Structural, Functional and Therapeutic Implications
Volume: 12 Issue: 3
Author(s): Vidyalatha Kolli, Subhankar Paul and Nandini Sarkar
Affiliation:
Keywords: Growth factors, cell surface receptors, cell differentiation, apoptosis, disease, mutations.
Abstract: Growth factors are proteins capable of stimulating cell growth, proliferation and differentiation. The Fibroblast Growth Factor (FGF) family is one of the largest growth factor families, comprising of a group of structurally & functionally related family of 22 polypeptide growth factors. FGFs play their physiological roles by binding to the high affinity FGF receptors (FGFRs) expressed on the surface of the target cells. These proteins are the key players in the cell growth, differentiation, migration, morphogenesis, embryonic development, wound healing, tumor growth etc. There are also reports on the involvement of FGFs in certain diseases. However FGFs have also been shown to have immense potential for use in therapeutics. This review is an attempt to provide an insight to the FGFs, their structural and functional aspects, key biological functions along with a brief account of their implication in diseases and therapeutic uses.
Export Options
About this article
Cite this article as:
Kolli Vidyalatha, Paul Subhankar and Sarkar Nandini, An Overview on Fibroblast Growth Factors: Structural, Functional and Therapeutic Implications, Current Proteomics 2015; 12 (3) . https://dx.doi.org/10.2174/157016461203151120093251
DOI https://dx.doi.org/10.2174/157016461203151120093251 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
Call for Papers in Thematic Issues
Mass spectrometry data acquisition and analysis for proteomics
The Thematic Issue on "Mass spectrometry data acquisition and analysis for proteomics" aims to explore the latest advancements and challenges in the field of proteomics through the lens of mass spectrometry. Proteomics, the large-scale study of proteins and their functions, plays a crucial role in understanding various biological processes and ...read more
Peptides: State-of-Art and Commercialisation Hurdles
The Editors of the Current Proteomics (CP) journal are highly privileged to welcome scientists to submit their scientific research and review articles to be considered for publication in the upcoming thematic issue. The topics should cover various aspects of peptides in regard to their synthetic methodologies, formulation approaches, pharmacological challenges, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cholesterol Lowering Therapy: Treat to Target or Reduce the Global Risk? The Unresolved Problem of Residual Risk
Current Pharmaceutical Design Modification of Lifestyle Factors are Needed to Improve the Metabolic Health of Patients with Cardiovascular Disease Risk
Current Pharmaceutical Design Recent Advances in Bioreactors in Tissue Engineering and Regenerative Medicine
Current Tissue Engineering (Discontinued) Membrane Lipids in the Function of Serotonin and Adrenergic Receptors
Current Medicinal Chemistry Pharmacological Management of Cardiac Disease in Patients with Type 2 Diabetes: Insights into Clinical Practice
Current Vascular Pharmacology A Review of the Characteristics, Properties and Methods for Quantification of Roxithromycin
Current Pharmaceutical Analysis Lipoic Acid as a Potential Therapy for Chronic Diseases Associated with Oxidative Stress
Current Medicinal Chemistry Generation of Human Cardiomyocytes for Cardiac Regenerative Therapies: Differentiation and Direct Reprogramming
Current Pharmaceutical Design Anti-inflammatory Treatment of Acute Coronary Syndromes
Current Pharmaceutical Design Relationships of Birthweight and Postnatal Growth with Metabolic Risk Factors in Junior School Children in Korea
Current Hypertension Reviews Meet Our Editorial Board Member
Current Medical Imaging Integrin Signaling Networks in the Pathobiology of Vascular Smooth Muscle Cells
Vascular Disease Prevention (Discontinued) Cardiac Tumors: Clinical Perspective and Therapeutic Considerations
Current Drug Targets Effect of Immunoglobulin Therapy on Blood Viscosity and potential concerns of Thromboembolism, Especially in Patients with Acute Kawasaki Disease
Recent Patents on Cardiovascular Drug Discovery A Brief History of ‘Lone’ Atrial Fibrillation: From ‘A Peculiar Pulse Irregularity’ to a Modern Public Health Concern
Current Pharmaceutical Design Antioxidants in the Practice of Medicine; What Should the Clinician Know?
Cardiovascular & Hematological Disorders-Drug Targets Editorial: The Need of Time: Development of New Antimicrobials
Current Topics in Medicinal Chemistry The Therapeutic Potential of Induced Pluripotent Stem Cells After Stroke: Evidence from Rodent Models
Current Stem Cell Research & Therapy Pentraxins: CRP and PTX3 and Cardiovascular Disease
Inflammation & Allergy - Drug Targets (Discontinued) Pharmacogenetic Modulation of Platelet Inhibition
Current Pharmacogenomics and Personalized Medicine