Abstract
A new family of non-ionic amphiphilic dendro-calix[4]arene bearing hydrophilic branched substituents at the upper rim and lipophilic alkyl chains at the lower rim was designed and synthesized. Micelles of various sizes are obtained due to the amphiphilic nature of the calix[4]arene derivatives in aqueous medium. The amphiphilic calix[4]arene derivatives effectively load hydrophobic dye such as alizarin yellow via secondary interactions such as hydrogen bonding and π-π stacking. The length of alkyl chain and the intrinsic cyclic nature of calixarene scaffold have shown a significant impact on the transport potential of all amphiphiles.
Keywords: Calix[4]arene, Self-assembly, Micelles, Encapsulation potential
Current Organic Chemistry
Title:Design, Synthesis, and Transport Potential of a New Family of Nonionic Amphiphilic Dendro-calix[4]arene
Volume: 16 Issue: 22
Author(s): Khalid Khan, Hong Huang and Yan-Song Zheng
Affiliation:
Keywords: Calix[4]arene, Self-assembly, Micelles, Encapsulation potential
Abstract: A new family of non-ionic amphiphilic dendro-calix[4]arene bearing hydrophilic branched substituents at the upper rim and lipophilic alkyl chains at the lower rim was designed and synthesized. Micelles of various sizes are obtained due to the amphiphilic nature of the calix[4]arene derivatives in aqueous medium. The amphiphilic calix[4]arene derivatives effectively load hydrophobic dye such as alizarin yellow via secondary interactions such as hydrogen bonding and π-π stacking. The length of alkyl chain and the intrinsic cyclic nature of calixarene scaffold have shown a significant impact on the transport potential of all amphiphiles.
Export Options
About this article
Cite this article as:
Khan Khalid, Huang Hong and Zheng Yan-Song, Design, Synthesis, and Transport Potential of a New Family of Nonionic Amphiphilic Dendro-calix[4]arene, Current Organic Chemistry 2012; 16 (22) . https://dx.doi.org/10.2174/138527212804004562
DOI https://dx.doi.org/10.2174/138527212804004562 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Anticancer Effects of Ginsenoside Rh2: A Systematic Review
Current Molecular Pharmacology Caspase-Independent Pathways of Programmed Cell Death: The Unraveling of New Targets of Cancer Therapy?
Current Cancer Drug Targets Translational Optical Imaging in Diagnosis and Treatment of Cancer
Current Pharmaceutical Biotechnology Recent Advances in the Development of Selective CB2 Agonists as Promising Anti-Inflammatory Agents
Current Medicinal Chemistry Cannabinoids: Occurrence and Medicinal Chemistry
Current Medicinal Chemistry Targeting Protein-Protein and Protein-Nucleic Acid Interactions for Anti-HIV Therapy
Current Pharmaceutical Design Animal Modeling of Cancer Pathology and Studying Tumor Response to Therapy
Current Drug Targets Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases
CNS & Neurological Disorders - Drug Targets Cholesterol in Alzheimers Disease: Unresolved Questions
Current Alzheimer Research Immunotherapy of Malignant Gliomas Using Autologous and Allogeneic Tissue Cells
Anti-Cancer Agents in Medicinal Chemistry The Emerging Role of Vascular Endothelial Growth Factor (VEGF) in Vascular Homeostasis: Lessons from Recent Trials with Anti-VEGF Drugs
Current Vascular Pharmacology Stimulation of Peroxisome Proliferator-Activated Receptor-Gamma (PPARγ) using Pioglitazone Decreases the Survival of Acute Promyelocytic Leukemia Cells through Up-Regulation of PTEN Expression
Anti-Cancer Agents in Medicinal Chemistry Glycoconjugates: Roles in Neural Diseases Caused by Exogenous Pathogens
CNS & Neurological Disorders - Drug Targets Mesenchymal Stem Cells in Cartilage Repair: State of the Art and Methods to monitor Cell Growth, Differentiation and Cartilage Regeneration
Current Medicinal Chemistry Resveratrol and Analogues: A Review of Antioxidant Activity and Applications to Human Health
Recent Patents on Food, Nutrition & Agriculture Gene Sets of Gene Ontology are More Stable Diagnostic Biomarkers than Genes in Oral Squamous Cell Carcinoma
Current Bioinformatics The 18 kDa Translocator Protein (TSPO): A New Perspective in Mitochondrial Biology
Current Molecular Medicine Melatonin and Aromatase in Breast Cancer
Clinical Cancer Drugs Targeting the Brain: Advances in Drug Delivery
Current Pharmaceutical Biotechnology Preclinical Evaluation of New Anthracyclines
Current Medicinal Chemistry