Abstract
An ideal drug must be absolutely inert in normal conditions, providing release of active compounds only in diseased areas. Nanoengineered polymeric capsules have required features. We describe here basic methods for the fabrication of such containers and give some particular examples of their use when the drug release is triggered by the presence of the disease itself or by the soft external action, with no side effects on the adjacent tissues.
Keywords: Ideal drug carrier, Layer-by-Layer electrostatic self-assembly, Polyelectrolyte capsules, Targeted drug delivery, Triggered drug release, Bacteriorhodopsin (BR), UV irradiation of azobenzene, Biocompatibilty, Confocal laser scanning microscopy (CLSM), Nanoengineered Polymeric Capsules
Current Organic Chemistry
Title:Smart Nanoengineered Polymeric Capsules as Ideal Pharmaceutical Carriers
Volume: 17 Issue: 1
Author(s): Laura Pastorino, Svetlana Erokhina and Victor Erokhin
Affiliation:
Keywords: Ideal drug carrier, Layer-by-Layer electrostatic self-assembly, Polyelectrolyte capsules, Targeted drug delivery, Triggered drug release, Bacteriorhodopsin (BR), UV irradiation of azobenzene, Biocompatibilty, Confocal laser scanning microscopy (CLSM), Nanoengineered Polymeric Capsules
Abstract: An ideal drug must be absolutely inert in normal conditions, providing release of active compounds only in diseased areas. Nanoengineered polymeric capsules have required features. We describe here basic methods for the fabrication of such containers and give some particular examples of their use when the drug release is triggered by the presence of the disease itself or by the soft external action, with no side effects on the adjacent tissues.
Export Options
About this article
Cite this article as:
Pastorino Laura, Erokhina Svetlana and Erokhin Victor, Smart Nanoengineered Polymeric Capsules as Ideal Pharmaceutical Carriers, Current Organic Chemistry 2013; 17 (1) . https://dx.doi.org/10.2174/138527213805289088
DOI https://dx.doi.org/10.2174/138527213805289088 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Kinase Inhibitors Targeting Anti-angiogenesis as Anti-cancer Therapies
Current Angiogenesis (Discontinued) Metastatic Colorectal Cancer: Prognostic and Predictive Factors
Current Medicinal Chemistry EGFR-Targeted Therapy in Malignant Glioma: Novel Aspects and Mechanisms of Drug Resistance
Current Molecular Pharmacology Targeting DNA Topoisomerase I with Non-Camptothecin Poisons
Current Medicinal Chemistry TGF-β in Epithelial to Mesenchymal Transition and Metastasis of Liver Carcinoma
Current Pharmaceutical Design Do Not Say Ever Never More: The Ins and Outs of Antiangiogenic Therapies
Current Pharmaceutical Design Editorial: The microRNA 221/222 Cluster: Inaugurating a New Era in Cardiovascular Disease and Cancer?
Current Vascular Pharmacology Metformin and Anti-Cancer Therapeutics: Hopes for a More Enhanced Armamentarium Against Human Neoplasias?
Current Medicinal Chemistry 5-Benzylidene-3,4-dihalo-furan-2-one derivatives inhibit human leukemia cancer cells through suppression of NF-κB and GSK-3β
Anti-Cancer Agents in Medicinal Chemistry Modelling DNA Repair Pathways: Recent Advances and Future Directions
Current Pharmaceutical Design Do We Have Another Option to Treat Bleeding Hemorrhoids? The Emborrhoid Technique: Experience in 16 Patients
Reviews on Recent Clinical Trials The Human L1 Element: A Potential Biomarker in Cancer Prognosis, Current Status and Future Directions
Current Molecular Medicine Screening and Identification of Differentially Expressed Genes Between Diabetic Nephropathy Glomerular and Normal Glomerular via Bioinformatics Technology
Combinatorial Chemistry & High Throughput Screening Viral-Mediated Gene Transfer for Cancer Treatment
Current Pharmaceutical Biotechnology microRNAs: Innovative Targets for Cerebral Ischemia and Stroke
Current Drug Targets Strategy of Cancer Targeting Gene-Viro-Therapy (CTGVT) a Trend in Both Cancer Gene Therapy and Cancer Virotherapy
Current Pharmaceutical Biotechnology Nanoemulsions for Improved Efficacy of Phytotherapeutics- A Patent Perspective
Recent Patents on Nanotechnology Recent Advances in Herbal Nanomedicines for Cancer Treatment
Current Molecular Pharmacology Ruthenium Complexes: An Emerging Ground to the Development of Metallopharmaceuticals for Cancer Therapy
Mini-Reviews in Medicinal Chemistry Cancer Therapeutics-Related Cardiovascular Complications. Mechanisms, Diagnosis and Treatment
Current Pharmaceutical Design