Abstract
The following review analyzes the most effective activation protocols for the generation of transient electrophilic quinone methides, merged into the recent strategies to achieve recognition and alkylation of nucleic acids. The covalent targeting has to be specific for selected oligonucleotide sequences (sequence-specificity) or for those oligonucleotides capable to fold into supramolecular structures, such as G-quadruplexes (structure-specificity). The reversibility of the DNA alkylation process by QM is reviewed underlining the opportunities (in term of selectivity and delivery) and drawbacks (in term of product characterization of the covalent damage) in the DNA targeting.
Keywords: Alkylation, cross-linking, nucleic acids, quinone methides, reversibility, sequence-specificity, structure-specificity.
Current Organic Chemistry
Title:Quinone Methides as DNA Alkylating Agents: An Overview on Efficient Activation Protocols for Enhanced Target Selectivity
Volume: 18 Issue: 1
Author(s): Claudia Percivalle, Filippo Doria and Mauro Freccero
Affiliation:
Keywords: Alkylation, cross-linking, nucleic acids, quinone methides, reversibility, sequence-specificity, structure-specificity.
Abstract: The following review analyzes the most effective activation protocols for the generation of transient electrophilic quinone methides, merged into the recent strategies to achieve recognition and alkylation of nucleic acids. The covalent targeting has to be specific for selected oligonucleotide sequences (sequence-specificity) or for those oligonucleotides capable to fold into supramolecular structures, such as G-quadruplexes (structure-specificity). The reversibility of the DNA alkylation process by QM is reviewed underlining the opportunities (in term of selectivity and delivery) and drawbacks (in term of product characterization of the covalent damage) in the DNA targeting.
Export Options
About this article
Cite this article as:
Percivalle Claudia, Doria Filippo and Freccero Mauro, Quinone Methides as DNA Alkylating Agents: An Overview on Efficient Activation Protocols for Enhanced Target Selectivity, Current Organic Chemistry 2014; 18 (1) . https://dx.doi.org/10.2174/13852728113176660135
DOI https://dx.doi.org/10.2174/13852728113176660135 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
New Therapeutic Applications of Phosphodiesterase 5 Inhibitors (PDE5-Is)
Current Medicinal Chemistry Editorial [Hot Topic: Novel Kinase Inhibitors in Cancer Therapy (Guest Editors: Ezra E.W. Cohen and Nikolai G. Rainov)]
Reviews on Recent Clinical Trials Chemokine Receptor-directed Agents as Novel Anti-HIV-1 Therapies
Current Topics in Medicinal Chemistry Autophagy in Diabetic Retinopathy
Current Neuropharmacology Multi-Target Drugs for Neglected Diseases
Current Pharmaceutical Design Adrenomedullin-RAMP2 System in Cardiovascular Development and Homeostasis
Current Hypertension Reviews Cholangiocarcinoma Therapeutics: An Update
Current Cancer Drug Targets Design of New Oxazaphosphorine Anticancer Drugs
Current Pharmaceutical Design Epidemiology, Clinical Presentation and Treatment of Mucosal Melanoma
Clinical Cancer Drugs RBM15 Functions in Blood Diseases
Current Cancer Drug Targets Chemical Advances in Therapeutic Application of Exosomes and Liposomes
Current Medicinal Chemistry Killing the Messenger: Antisense DNA and siRNA
Current Drug Targets A Link Between Chemical Structure and Biological Activity in Triterpenoids
Recent Patents on Anti-Cancer Drug Discovery Interleukin-26, a Highly Cationic T-Cell Cytokine Targeting Epithelial Cells
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Molecular Pharmacology and Pharmacogenomics of Artemisinin and its Derivatives in Cancer Cells
Current Drug Targets Skin Cancers in Elderly Patients
Anti-Cancer Agents in Medicinal Chemistry Monocytes Mediate HIV Neuropathogenesis: Mechanisms that Contribute to HIV Associated Neurocognitive Disorders
Current HIV Research Antimetastatic Activities and Mechanisms of Bisdioxopiperazine Compounds
Anti-Cancer Agents in Medicinal Chemistry Prevalence of HIV in Patients with Malignancy and of Malignancy in HIV Patients in a Tertiary Care Center from North India
Current HIV Research Genetic Determinants of Amyotrophic Lateral Sclerosis as Therapeutic Targets
CNS & Neurological Disorders - Drug Targets