Abstract
Tuberculosis (TB) is a major cause of illness and death. The worldwide epidemic of HIV/AIDS and emergence of multidrug-resistant and extensively drug-resistant TB, are exacerbating this global public health issue. In this situation, several innovative approaches are being pursued to further improve the existing measures, as well as to identify new one. Recently, stem cell transplantation has emerged as a novel therapeutic option which holds promises for the treatment of many non-infectious and infectious diseases. Recent advances and experimental studies attracted the interest of researchers for exploring the stem cellbased treatment as a candidate treatment option for drug resistant tuberculosis. To date little has been published concerning the short and long term therapeutic effect of any type of stem cells in patients suffering from drug resistant tuberculosis. The purpose of this review is to present the viewpoints on current status and future prospect of this novel treatment approach in severe form of TB and also to discuss the opportunities and challenges associated with this approach.
Keywords: Extensively drug resistant tuberculosis, multidrug resistant tuberculosis, mesenchymal stem cells, Mycobacterium tuberculosis, stem cells, tuberculosis.
Current Respiratory Medicine Reviews
Title:Progress and Prospects of Stem Cells in Treatment of Drug Resistant Tuberculosis
Volume: 10 Issue: 4
Author(s): Pravin Kumar Singh and Amita Jain
Affiliation:
Keywords: Extensively drug resistant tuberculosis, multidrug resistant tuberculosis, mesenchymal stem cells, Mycobacterium tuberculosis, stem cells, tuberculosis.
Abstract: Tuberculosis (TB) is a major cause of illness and death. The worldwide epidemic of HIV/AIDS and emergence of multidrug-resistant and extensively drug-resistant TB, are exacerbating this global public health issue. In this situation, several innovative approaches are being pursued to further improve the existing measures, as well as to identify new one. Recently, stem cell transplantation has emerged as a novel therapeutic option which holds promises for the treatment of many non-infectious and infectious diseases. Recent advances and experimental studies attracted the interest of researchers for exploring the stem cellbased treatment as a candidate treatment option for drug resistant tuberculosis. To date little has been published concerning the short and long term therapeutic effect of any type of stem cells in patients suffering from drug resistant tuberculosis. The purpose of this review is to present the viewpoints on current status and future prospect of this novel treatment approach in severe form of TB and also to discuss the opportunities and challenges associated with this approach.
Export Options
About this article
Cite this article as:
Kumar Singh Pravin and Jain Amita, Progress and Prospects of Stem Cells in Treatment of Drug Resistant Tuberculosis, Current Respiratory Medicine Reviews 2014; 10 (4) . https://dx.doi.org/10.2174/1573398X10666140701175259
DOI https://dx.doi.org/10.2174/1573398X10666140701175259 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pleiotropic Regulatory Genes as A Tool for <i>Streptomyces</i> Strains Bioprospecting and Improvement
Current Biotechnology Chemical Constituents from the Chinese Bryophytes and Their Reversal of Fungal Resistance
Current Organic Chemistry Recent Developments in Azole Compounds as Antitubercular Agent
Mini-Reviews in Organic Chemistry Phytoconstituents of <i>Lantana camara</i> L.: Rekindling Hope in the Cancer Treatment
Current Bioactive Compounds Regulation of Inflammation: A Review of Recent Advances in Anti- Inflammatory Strategies
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents The Biological and Clinical Activity of Anti-Malarial Drugs In Autoimmune Disorders
Current Rheumatology Reviews Ethnic Differences in Pharmacogenetically Relevant Genes
Current Drug Targets Modified and Mutant Porins in the Study on Molecular Basis of Non- Specific Diffusion
Current Protein & Peptide Science Synthesis, In Vitro Activities of (2-Cyclopropoxyphenyl)piperidine Derivatives for α1a and α1d Adrenergic Receptor Inhibitors
Medicinal Chemistry Mycobacterial DNA Replication as a Target for Antituberculosis Drug Discovery
Current Topics in Medicinal Chemistry Pharmacological and Biological Activities of Xanthones
Anti-Infective Agents in Medicinal Chemistry Life Threatening and Fatal Contrast Media Reactions: Pathomechanisms, Diagnosis, Prevention and Drug Management
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry A Mathematical Approach for the Simultaneous In Vitro Spectrophotometric Analysis of Rifampicin and Isoniazid from Modified-Release Anti-TB Drug Delivery Systems
Current Drug Delivery Recent Advances in Computer-Aided Drug Design as Applied to Anti-Influenza Drug Discovery
Current Topics in Medicinal Chemistry Towards the Design and Development of Agents with Broad Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV / AIDS
Current Medicinal Chemistry Carnitine Metabolism and Deficit - When Supplementation is Necessary?
Current Pharmaceutical Biotechnology In vitro Anti-Mycobacterial Activities of Various 2-Deoxyuridine, 2- Arabinouridine and 2-Arabinofluoro-2-deoxyuridine Analogues: Synthesis and Biological Studies
Medicinal Chemistry Formulation of Nanoparticles Against TB - A Review
Recent Patents on Inflammation & Allergy Drug Discovery Organic Antifungal Drugs and Targets of Their Action
Current Topics in Medicinal Chemistry Recent Patents of Gene Sequences Relative to DNA Polymerases
Recent Patents on DNA & Gene Sequences