Abstract
During tumor progression, several types of inflammatory cells are recruited into the tumor site, where they participate in tumor-associated inflammation, such as fibroblasts, granulocytes, lymphocytes and macrophages. Macrophages infiltrating into the tumor microenvironment are termed tumorassociated macrophages (TAMs). In response to multiple stimuli, macrophages undergo recruitment and polarization, and play an important role in further tumor development. In this article, we present a review of the mechanism of macrophage’ recruitment, and the role that TAMs play in promoting immunosuppression, tumor progress and metastasis, as well as chemoresistance and future therapeutic strategies.
Keywords: Tumor associated macrophages, tumor microenvironment, pancreatic cancer, breast cancer, lung cancer, lymphoma.
Anti-Cancer Agents in Medicinal Chemistry
Title:The Role of Tumor Associated Macrophages in the Tumor Microenvironment: Mechanism and Functions
Volume: 16 Issue: 9
Author(s): Jie Zhu, Qiaoming Zhi, Binhua P. Zhou, Min Tao, Jingyi Liu and Wei Li
Affiliation:
Keywords: Tumor associated macrophages, tumor microenvironment, pancreatic cancer, breast cancer, lung cancer, lymphoma.
Abstract: During tumor progression, several types of inflammatory cells are recruited into the tumor site, where they participate in tumor-associated inflammation, such as fibroblasts, granulocytes, lymphocytes and macrophages. Macrophages infiltrating into the tumor microenvironment are termed tumorassociated macrophages (TAMs). In response to multiple stimuli, macrophages undergo recruitment and polarization, and play an important role in further tumor development. In this article, we present a review of the mechanism of macrophage’ recruitment, and the role that TAMs play in promoting immunosuppression, tumor progress and metastasis, as well as chemoresistance and future therapeutic strategies.
Export Options
About this article
Cite this article as:
Zhu Jie, Zhi Qiaoming, Zhou P. Binhua, Tao Min, Liu Jingyi and Li Wei, The Role of Tumor Associated Macrophages in the Tumor Microenvironment: Mechanism and Functions, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (9) . https://dx.doi.org/10.2174/1871520616666160520112622
DOI https://dx.doi.org/10.2174/1871520616666160520112622 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
Call for Papers in Thematic Issues
Induction of cell death in cancer cells by modulating telomerase activity using small molecule drugs
Telomeres are distinctive but short stretches present at the corners of chromosomes and aid in stabilizing chromosomal makeup. Resynthesis of telomeres supported by the activity of reverse transcriptase ribonucleoprotein complex telomerase. There is no any telomerase activity in human somatic cells, but the stem cells and germ cells undergone telomerase ...read more
Role of natural compounds as anti anti-cancer agents
Cancer is considered the leading cause of worldwide mortality, accounting for nearly 10 million deaths in 2022. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy remains an important approach in treatment o f several types of cancers, even though ...read more
Signaling and enzymatic modulators in cancer treatment
Cancer accounts for nearly 10 million deaths in 2022 and is considered the leading cause of worldwide mortality. Cancer outcome can be improved through an appropriate screening and early detection and through an efficient clinical treatment. Chemotherapy, radiotherapy and surgery are the most important approach for the treatment of several ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Clinical Significance of Indocyanine Green Excretion Test in Evaluation of Liver Functional Reserve
Current Signal Transduction Therapy Alternative Polyadenylation and Its Impact on Cellular Processes
MicroRNA Interferon: Cellular Executioner or White Knight?
Current Medicinal Chemistry DNMT Inhibitors in Cancer, Current Treatments and Future Promising Approach: Inhibition of Specific DNMT-Including Complexes
Epigenetic Diagnosis & Therapy (Discontinued) Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes
Current Gene Therapy Novel Therapeutic Approaches to Autoimmune Demyelinating Disorders
Current Pharmaceutical Design Lipid Based Nanoparticles as Inherent Reversing Agents of Multidrug Resistance in Cancer
Current Pharmaceutical Design Nitric Oxide and the Regulation of Apoptosis in Tumour Cells
Current Pharmaceutical Design Computational and Experimental Studies on Human Misshapen / NIK- Related Kinase MINK-1
Current Medicinal Chemistry Is There a Clinical Future for Spermatogonial Stem Cells?
Current Stem Cell Research & Therapy Neurological Involvement in Rheumatoid Arthritis
Current Immunology Reviews (Discontinued) Medical and Dental Implications of Down Syndrome: A Review Part 1: General and Craniofacial Characteristic
Applied Clinical Research, Clinical Trials and Regulatory Affairs Recent Advances in the Development of Selective Mcl-1 Inhibitors for the Treatment of Cancer (2017-Present)
Recent Patents on Anti-Cancer Drug Discovery Newborn Screening through TREC, TREC/KREC System for Primary Immunodeficiency with limitation of TREC/KREC. Comprehensive Review
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Function and Regulation of Let-7 Family microRNAs
MicroRNA Role of miRNAs in Muscle Stem Cell Biology: Proliferation, Differentiation and Death
Current Pharmaceutical Design Role of Oxidative Stress in Hepatitis C Virus Induced Hepatocellular Carcinoma
Current Cancer Drug Targets Ring Opening of Tetrazole via Unusual Vilsmeir-Haack Reaction Forming Novel Triazenes
Letters in Organic Chemistry Cardiovascular Complications of HIV Infection and Treatment
Cardiovascular & Hematological Agents in Medicinal Chemistry Current Developments of Coumarin Compounds in Medicinal Chemistry
Current Pharmaceutical Design