Abstract
Background: Cancer medically, is a group of wide range of several diseases which are related with uncontrolled growth process of cells. A cross-sectional study was carried out to assess the concentration of cadmium (Cd), copper (Cu), lead (Pb) and zinc (Zn) in blood serum samples of cancer patients in comparison with healthy/control subjects.
Methods: A total of sixty subjects (30 cancer patients and 30 healthy subjects) were selected for this study from different hospitals of Karachi, Pakistan. Whole blood samples collected, digested and analyzed through graphite furnace atomic absorption spectrometry (GFAAS) for elemental analysis. Results: The results showed that the concentrations of these metals in blood serum of cancer patients were higher than healthy subjects. The mean concentration of Cd, Cu, Pb and Zn were 2.12, 1237.03, 1.87, 1084.74 µg/L respectively. The statistical data obtained was correlated to find the possible interaction between different metals. A negative correlation was observed between Pb/Zn (r = -0.521) in cancer and Cu/Zn (r= -0.431) in healthy individuals. Conclusion: The trend of metals in blood samples of cancer’s patients are as follows: Cu > Zn > Pb > Cd and in healthy individuals are: Zn > Cu > Pb > Cd. The statistical data reveals that there are significant differences found in between healthy and cancers individuals. Regular monitoring study should be carried out to create awareness on metal toxicity.Keywords: Blood, cancer patients, correlation, GFAAS, heavy metals, atomic absorption spectrometry.
Current Analytical Chemistry
Title:Concentrations of Cd, Cu, Pb and Zn in Blood Serum of Cancer Patients and Comparison with Healthy Person by Atomic Absorption Spectrometry
Volume: 13 Issue: 5
Author(s): M. Hafsa, Kousar Yasmeen*, Faheem Shah*, Sajid Jahangir, Atta-ur-Rahman and Aiman Manzar
Affiliation:
- Department of Chemistry, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi-75300,Pakistan
- Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060,Pakistan
Keywords: Blood, cancer patients, correlation, GFAAS, heavy metals, atomic absorption spectrometry.
Abstract: Background: Cancer medically, is a group of wide range of several diseases which are related with uncontrolled growth process of cells. A cross-sectional study was carried out to assess the concentration of cadmium (Cd), copper (Cu), lead (Pb) and zinc (Zn) in blood serum samples of cancer patients in comparison with healthy/control subjects.
Methods: A total of sixty subjects (30 cancer patients and 30 healthy subjects) were selected for this study from different hospitals of Karachi, Pakistan. Whole blood samples collected, digested and analyzed through graphite furnace atomic absorption spectrometry (GFAAS) for elemental analysis. Results: The results showed that the concentrations of these metals in blood serum of cancer patients were higher than healthy subjects. The mean concentration of Cd, Cu, Pb and Zn were 2.12, 1237.03, 1.87, 1084.74 µg/L respectively. The statistical data obtained was correlated to find the possible interaction between different metals. A negative correlation was observed between Pb/Zn (r = -0.521) in cancer and Cu/Zn (r= -0.431) in healthy individuals. Conclusion: The trend of metals in blood samples of cancer’s patients are as follows: Cu > Zn > Pb > Cd and in healthy individuals are: Zn > Cu > Pb > Cd. The statistical data reveals that there are significant differences found in between healthy and cancers individuals. Regular monitoring study should be carried out to create awareness on metal toxicity.Export Options
About this article
Cite this article as:
Hafsa M., Yasmeen Kousar*, Shah Faheem*, Jahangir Sajid, Atta-ur-Rahman and Manzar Aiman, Concentrations of Cd, Cu, Pb and Zn in Blood Serum of Cancer Patients and Comparison with Healthy Person by Atomic Absorption Spectrometry, Current Analytical Chemistry 2017; 13 (5) . https://dx.doi.org/10.2174/1573411013666161205164454
DOI https://dx.doi.org/10.2174/1573411013666161205164454 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
Call for Papers in Thematic Issues
Advancements in biomedicine, corrosion inhibition/monitoring, and lubrication of carbon dots
Carbon dots, a class of carbon-based nanomaterials, have garnered substantial interest in various scientific and engineering fields due to their unique properties, including excellent optical properties, outstanding biocompatibility, easy preparation, good dispersity, ultrasmall size, low toxicity and environmental friendliness. This special issue of Current Analytical Chemistry aims to showcase cutting-edge ...read more
Advances in Microfluidic and Sensing Technologies of Biofluids.
Detection of biological fluids is an important means to assess human health and diagnose diseases. Currently, research on blood is relatively mature and widely applied in the medical field. With the development and advancement of microfluidic technology and novel detection methods, attention has turned to human physiological fluids such as ...read more
Analytical methods for environmental and food analysis
In recent years, the study of the chemical composition of food and the environment depends on analytical methods in order to acquire information about the chemical composition, processing, quality control and contamination of soil, water, air, plants and foods, aspects very important for food safety and environmental quality control. There ...read more
Applications of artificial intelligence in chemical analysis
Artificial intelligence (AI) has demonstrated its versatility in almost all scientific fields, especially analytical chemistry, which is leading the way in the integration of AI. According to Chemical Abstract Services, one of the major disciplines contributing to AI-related publications and patents is analytical chemistry. That?s because techniques such as deep ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Albumin-Based Nanodevices as Drug Carriers
Current Pharmaceutical Design miR-143: A Novel Regulator of MyoD Expression in Fast and Slow Muscles of Siniperca chuatsi
Current Molecular Medicine The Role of Phenolic Compounds in the Fight against Cancer – A Review
Anti-Cancer Agents in Medicinal Chemistry Epigenetic Modification Restores Functional PR Expression in Endometrial Cancer Cells
Current Pharmaceutical Design Potential Use of Polymeric Nanoparticles for Drug Delivery Across the Blood-Brain Barrier
Current Medicinal Chemistry Signal Transduction Targets in Prostate Cancer
Current Signal Transduction Therapy Peptides Targeting Estrogen Receptor Alpha-Potential Applications for Breast Cancer Treatment
Current Pharmaceutical Design Melanoma Immunotherapy: Past, Present, and Future
Current Pharmaceutical Design Lynch Syndrome Identification in Endometrial Cancer Patients: Should Universal Screening be Used for all Histologies?
Current Women`s Health Reviews The Antiprogestogen Mifepristone: A Review
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Interrelationships of Circulating Tumor Cells with Metastasis and Thrombosis: Role of MicroRNAs
Current Pharmaceutical Design Redox Signaling Pathways Involved in Neuronal Ischemic Preconditioning
Current Neuropharmacology Recent Advances in the Development of Phytoestrogens and Derivatives: An Update of the Promising Perspectives in the Prevention of Postmenopausal Diseases
Mini-Reviews in Medicinal Chemistry Harnessing the Tumor Suppressor Function of FOXO as an Alternative Therapeutic Approach in Cancer
Current Drug Targets Angiogenesis-Related Cytokines in Rheumatoid Arthritis
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) PI3K Pathway Inhibitors: Better Not Left Alone
Current Pharmaceutical Design Autophagy: Molecular Mechanisms and their Implications for Anticancer Therapies
Current Cancer Drug Targets Repressing the Activity of Protein Kinase CK2 Releases Mitochondria-Mediated Apoptosis in Cancer Cells
Current Drug Targets Long Non-Coding RNA GAS5 in Age-Related Diseases
Current Medicinal Chemistry Utility of MLH1 Methylation Analysis in the Clinical Evaluation of Lynch Syndrome in Women with Endometrial Cancer
Current Pharmaceutical Design