Abstract
Background: All cancers are leading causes of morbidity and mortality worldwide. The urgent need for new lead compounds for the treatment of cancer is higher than ever before. Scientists search and try to discover effective but less harmful new anti-tumor agents. Surgery, chemotherapy and radiation are the bestknown methods for treating cancer, however, they continued to be limited. Rising efforts of the scientists toward success of the drug discovery is increasing. Indole ring is considered as a key molecule existing in various biologically active compounds. Indole derivatives are recognized to prevent proliferation and invasion of many cancer cells.
Conclusion: This review presents the existing status and the very recent studies of indoles which have promising activities such as derivatives of indole-3-carbinol, 3,3'-diindolylmethane (DIM), isatin etc. Their chemical and biological behavior as well as a general overview of the anticancer activity is discussed.
Keywords: Antioxidant, anticancer, carcinogenesis, DNA mutation, drug development, oxidative stress.
Current Organic Chemistry
Title:Recent Studies and Biological Aspects of Substantial Indole Derivatives with Anti-cancer Activity
Volume: 21 Issue: 20
Author(s): Sibel Suzen*
Affiliation:
- Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan-06100, Ankara,Turkey
Keywords: Antioxidant, anticancer, carcinogenesis, DNA mutation, drug development, oxidative stress.
Abstract: Background: All cancers are leading causes of morbidity and mortality worldwide. The urgent need for new lead compounds for the treatment of cancer is higher than ever before. Scientists search and try to discover effective but less harmful new anti-tumor agents. Surgery, chemotherapy and radiation are the bestknown methods for treating cancer, however, they continued to be limited. Rising efforts of the scientists toward success of the drug discovery is increasing. Indole ring is considered as a key molecule existing in various biologically active compounds. Indole derivatives are recognized to prevent proliferation and invasion of many cancer cells.
Conclusion: This review presents the existing status and the very recent studies of indoles which have promising activities such as derivatives of indole-3-carbinol, 3,3'-diindolylmethane (DIM), isatin etc. Their chemical and biological behavior as well as a general overview of the anticancer activity is discussed.
Export Options
About this article
Cite this article as:
Suzen Sibel *, Recent Studies and Biological Aspects of Substantial Indole Derivatives with Anti-cancer Activity, Current Organic Chemistry 2017; 21 (20) . https://dx.doi.org/10.2174/1385272821666170809143233
DOI https://dx.doi.org/10.2174/1385272821666170809143233 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nuclear Magnetic Resonance Spectroscopy of Lipids in Cancer
Current Organic Chemistry Design and Synthesis of 3,4-diarylpyrrole Analogues as Potent Topoisomerase Inhibitors
Medicinal Chemistry Costimulation, Coinhibition and Cancer
Current Cancer Drug Targets An Effective Vaccination Approach Augments Anti-HIV Systemic and Vaginal Immunity in Mice with Decreased HIV-1 Susceptible α4β7high CD4+ T Cells
Current HIV Research Phytochemicals as Adjunctive with Conventional Anticancer Therapies
Current Pharmaceutical Design Trichothecin from Endophytic Fungus Trichothecium sp. and its Anticancer Effect on Murine Melanoma and Breast Cancer Cell Lines
Current Biochemical Engineering (Discontinued) The ATP-driven Hsp60 Machinery: Biological and Clinical Implications
Current Immunology Reviews (Discontinued) Targeting Tumor Lymphangiogenesis: An Update
Current Medicinal Chemistry Advances in Regulating Tumorigenicity and Metastasis of Cancer Through TrkB Signaling
Current Cancer Drug Targets Effect of Monoamine Oxidase Inhibition on Rewarding Effects of Nicotine in Rodents
Current Drug Abuse Reviews Theoretical Modeling of HPV: QSAR and Novodesign with Fragment Approach
Current Computer-Aided Drug Design Perspectives On Membrane-associated Progesterone Receptors As Prospective Therapeutic Targets
Current Drug Targets Base-Modified Nucleosides as Chemotherapeutic Agents: Past and Future
Current Topics in Medicinal Chemistry Dynamic Contrast-Enhanced MRI in Oncology Drug Development
Current Clinical Pharmacology Hypermethylation of Single CpG Dinucleotides at the Promoter of CXCL13 Gene Promoting Cell Migration in Cervical Cancer
Current Cancer Drug Targets LDH Nanocontainers as Bio-Reservoirs and Drug Delivery Carriers
Recent Patents on Nanotechnology Issues in the Psychiatric Screening of Cancer Patients
Current Psychiatry Reviews Nasal Drug Delivery System-Factors Affecting and Applications
Current Drug Therapy Synthesis of 9-O-3-(1-piperazinyl/morpholinyl/piperidinyl)pentyl-berberines as Potential Antioxidant and Cytotoxic Agents
Anti-Cancer Agents in Medicinal Chemistry Autophagy Regulators as Potential Cancer Therapeutic agents: A Review
Current Topics in Medicinal Chemistry