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Current Respiratory Medicine Reviews

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ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

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Research Article

Investigating COVID-19 Severity Based on Serum Apelin-17 Levels and Inflammatory Mediators

Author(s): Mitra Samareh Fekri*, Elham Barfzade, Mehrdad Farokhnia, Seyed Mehdi Hashemi Bajgani, Ahmad Shafahi, Mohsen Shafiepour, Sajjadeh Movahedinia, Shariar Dabiri and Meysam Yousefi

Volume 18, Issue 1, 2022

Published on: 07 March, 2022

Page: [65 - 71] Pages: 7

DOI: 10.2174/1573398X18666220210145349

Price: $65

Abstract

Background: COVID-19 is an infectious disease caused by SARS-CoV-2 and can lead to acute respiratory distress.

Objective: We aimed to investigate the association between COVID-19 severity and serum apelin- 17 and inflammatory mediator levels.

Methods: This cross-sectional study was conducted on patients with COVID-19. COVID-19 infection was confirmed by the RT-PCR test. The patients' data were extracted from their records. Venous blood samples were obtained from the patients to investigate the serum levels of apelin-17 and inflammatory mediators.

Results: Eighty-six COVID-19 patients were studied. The mean age of the participants was 55.56±14.88, and 43 (50 %) were male. Clinical symptoms were dyspnea 77.6 %, fever 52.3 %, cough 48.8 %, gastrointestinal symptoms 15.1 %, and chest pain 7 %. The overall mortality rate was 7 %. No significant relationship was found between serum apelin-17 levels and COVID-19 severity (P= 0.48). However, there was a significant and direct relationship between COVID-19 severity and serum levels of CRP (P= 0.038) and D-dimer (P= 0.029).

Conclusion: Serum apelin-17 levels were higher in recovered patients than those who died (4.90 vs. 3.19). Moreover, serum apelin-17 levels were higher in the patients admitted to the general ward than those admitted to the ICU (5.15 vs. 3.98). The difference was not statistically significant. However, there was a significant and direct relationship between serum apelin-17 levels and lymphocyte count (P= 0.022). Moreover, there was a significant and inverse relationship between lymphocyte count and COVID-19 severity (P= 0.004). Therefore, it can be interpreted that COVID-19 severity may decrease with an increase in serum apelin-17 levels. Therefore, to prove this hypothesis, a study with larger sample size is recommended.

Keywords: Severity, COVID-19, Apelin, D-dimer, C-reactive protein, pneumonia.

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