Abstract
Reactive oxygen species (ROS) such as superoxide anion radical (O2-. ) play an essential role on normal cellular growth and homeostasis. However, excess ROS generated by perturbing O2-. homeostasis under various conditions of oxidative stress induce high radical toxicity, resulting in many diseases such as cancer, brain and myocardial infarction, and inflammation. Quantitative analysis of O2-. by a convenient method is a subject of intense research, since most of ROS are derived from O2-. . In situ real-time measurement of O2-. is very important to understand the relevance of ROS to many diseases. Recent progress in electrochemical sensors for the facile detection of O2-. , including biosensors utilizing a variety of metalloproteins as sensing elements for O2-. and very recently developed all-synthetic sensors with a high selectivity for O2-. detection, is reviewed. Emphasis is placed on the possibility of the all-synthetic sensor for convenient in vivo measurement of ROS.
Keywords: photodynamic therapy, DNA cleavage, BIOSENSORS, Superoxide Dismutase, Iron protoporphyrin, microelectrode
Current Organic Chemistry
Title: Electrochemical Detection and Sensing of Reactive Oxygen Species
Volume: 9 Issue: 16
Author(s): Makoto Yuasa and Kenichi Oyaizu
Affiliation:
Keywords: photodynamic therapy, DNA cleavage, BIOSENSORS, Superoxide Dismutase, Iron protoporphyrin, microelectrode
Abstract: Reactive oxygen species (ROS) such as superoxide anion radical (O2-. ) play an essential role on normal cellular growth and homeostasis. However, excess ROS generated by perturbing O2-. homeostasis under various conditions of oxidative stress induce high radical toxicity, resulting in many diseases such as cancer, brain and myocardial infarction, and inflammation. Quantitative analysis of O2-. by a convenient method is a subject of intense research, since most of ROS are derived from O2-. . In situ real-time measurement of O2-. is very important to understand the relevance of ROS to many diseases. Recent progress in electrochemical sensors for the facile detection of O2-. , including biosensors utilizing a variety of metalloproteins as sensing elements for O2-. and very recently developed all-synthetic sensors with a high selectivity for O2-. detection, is reviewed. Emphasis is placed on the possibility of the all-synthetic sensor for convenient in vivo measurement of ROS.
Export Options
About this article
Cite this article as:
Yuasa Makoto and Oyaizu Kenichi, Electrochemical Detection and Sensing of Reactive Oxygen Species, Current Organic Chemistry 2005; 9 (16) . https://dx.doi.org/10.2174/138527205774610921
DOI https://dx.doi.org/10.2174/138527205774610921 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Beta-Caryophyllene, a CB2R Selective Agonist, Protects Against Cognitive Impairment Caused by Neuro-inflammation and Not in Dementia Due to Ageing Induced by Mitochondrial Dysfunction
CNS & Neurological Disorders - Drug Targets The Biology of p38 Kinase: A Central Role in Inflammation
Current Topics in Medicinal Chemistry Transcriptional and Non-transcriptional Regulation of Glucose Metabolism and Insulin Sensitivity through Vitamin D
Current Nutrition & Food Science Modulation of the TRPV1 Channel: Current Clinical Trials and Recent Patents with Focus on Neurological Conditions
Recent Patents on CNS Drug Discovery (Discontinued) Immunomodulatory Effect of Cytokines in the Differentiation of Mesenchymal Stem Cells: A Review
Current Stem Cell Research & Therapy The Role of IRE1 Signaling in the Central Nervous System Diseases
Current Neuropharmacology Medicinal Chemistry Approaches of Controlling Gastrointestinal Side Effects of Non-Steroidal Anti-Inflammatory Drugs. Endogenous Protective Mechanisms and Drug Design
Medicinal Chemistry TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli
Current Neuropharmacology Effect of Human Umbilical Cord Blood Progenitor Cells Versus Mononuclear Cells on Acute Renal Failure Rat Model
Current Stem Cell Research & Therapy Modulation of Staurosporine-Activated Volume-Sensitive Outwardly Rectifying Cl- Channel by PI3K/Akt in Cardiomyocytes
Current Pharmaceutical Design Humanized Cobra Venom Factor: Experimental Therapeutics for Targeted Complement Activation and Complement Depletion
Current Pharmaceutical Design microRNA as Biomarkers and Regulator of Cardiovascular Development and Disease
Current Pharmaceutical Design A Novel Botulinum Toxin TAT-EGFP-HCS Fusion Protein Capable of Specific Delivery Through the Blood-brain Barrier to the Central Nervous System
CNS & Neurological Disorders - Drug Targets Suppression of TLR Signaling by Targeting TIR domain-Containing Proteins
Current Protein & Peptide Science Radial Approach for Percutaneous Coronary Intervention
Reviews on Recent Clinical Trials Fish Oil Prevents Oxidative Stress and Exerts Sustained Antiamnesic Effect After Global Cerebral Ischemia
CNS & Neurological Disorders - Drug Targets New Kid on the Block: Does Histamine Get Along with Inflammation in Amyotrophic Lateral Sclerosis?
CNS & Neurological Disorders - Drug Targets New Generation Calcium Channel Blockers in Hypertensive Treatment
Current Hypertension Reviews Toll-Like Receptors: Sensor Molecules for Detecting Damage to the Nervous System
Current Protein & Peptide Science Neuropharmacological Aspects of Crocus sativus L.: A Review of Preclinical Studies and Ongoing Clinical Research
CNS & Neurological Disorders - Drug Targets