Abstract
Approximately 15% of cerebral strokes in adults are due to bleeding into the brain (intracerebral hemorrhage, ICH). This can be related to hypertension, vascular anomalies, or coagulopathy. Prognosis following ICH is worse than that following ischemic stroke. In addition, head trauma and premature birth are associated with ICH. Inflammation occurs after ICH and might be an important part of the pathogenesis of brain damage. The goal of this review is to bring together recent diverse data concerning inflammation after ICH. There has been little investigation of the role of inflammation following ICH despite the fact that inflammation is more severe than in ischemic stroke. Inflammation in the brain follows a temporal sequence similar to that in other organs. Some cytokines and inflammatory cells may possess dual roles both deleterious and beneficial to brain after ICH. At present, experimental data only weakly support pursuit of pharmacologic anti-inflammatory strategies following ICH.
Keywords: inflammation, cytokines, adhesion molecules, leukocytes, ich, brain trauma, animal models, anti-inflammation
Current Neuropharmacology
Title: Brain Inflammation Following Intracerebral Hemorrhage
Volume: 1 Issue: 4
Author(s): Mengzhou Xue, Janani Balasubramaniam and Marc R. Del Bigio
Affiliation:
Keywords: inflammation, cytokines, adhesion molecules, leukocytes, ich, brain trauma, animal models, anti-inflammation
Abstract: Approximately 15% of cerebral strokes in adults are due to bleeding into the brain (intracerebral hemorrhage, ICH). This can be related to hypertension, vascular anomalies, or coagulopathy. Prognosis following ICH is worse than that following ischemic stroke. In addition, head trauma and premature birth are associated with ICH. Inflammation occurs after ICH and might be an important part of the pathogenesis of brain damage. The goal of this review is to bring together recent diverse data concerning inflammation after ICH. There has been little investigation of the role of inflammation following ICH despite the fact that inflammation is more severe than in ischemic stroke. Inflammation in the brain follows a temporal sequence similar to that in other organs. Some cytokines and inflammatory cells may possess dual roles both deleterious and beneficial to brain after ICH. At present, experimental data only weakly support pursuit of pharmacologic anti-inflammatory strategies following ICH.
Export Options
About this article
Cite this article as:
Xue Mengzhou, Balasubramaniam Janani and Bigio R. Del Marc, Brain Inflammation Following Intracerebral Hemorrhage, Current Neuropharmacology 2003; 1 (4) . https://dx.doi.org/10.2174/1570159033477008
DOI https://dx.doi.org/10.2174/1570159033477008 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Neuroprotection by the α2-Adrenoceptor Agonist, Dexmedetomidine, in Experimental Stroke Models
Vascular Disease Prevention (Discontinued) Role of Heme Oxygenase-1 in Vascular Disease
Current Pharmaceutical Design Pigment Epithelium-Derived Factor (PEDF) Blocks Angiotensin IIInduced T Cell Proliferation by Suppressing Autocrine Production of Interleukin-2
Medicinal Chemistry Interactions Between the Sympathetic Nervous System and Angiotensin System in Renovascular Hypertension
Current Hypertension Reviews Epoxyeicosatrienoic Acid Analogs and Vascular Function
Current Medicinal Chemistry A Review on Novel Ligand Targeted Delivery for Cardiovascular Disorder
Current Drug Delivery Role of Infrasound Pressure Waves in Atherosclerotic Plaque Rupture: A theoretical Approach
Recent Patents on Cardiovascular Drug Discovery Insulin and the Future Treatment of Alzheimer’s Disease
CNS & Neurological Disorders - Drug Targets Dietary Fatty Acids in Metabolic Syndrome, Diabetes and Cardiovascular Diseases
Current Diabetes Reviews Nitric Oxide, Epileptic Seizures, and Action of Antiepileptic Drugs
CNS & Neurological Disorders - Drug Targets Exercise and Cardiovascular Disease
Cardiovascular & Hematological Disorders-Drug Targets Polypeptide Toxins from Animal Venoms
Recent Patents on DNA & Gene Sequences Cardioprotective Effects of Sour Cherry Seed Extract (SCSE) on the Hypercholesterolemic Rabbit Heart
Current Pharmaceutical Design Autologous Hematopoietic Stem Cell Transplantation for Systemic Sclerosis
Current Stem Cell Research & Therapy Reproductive Health Indicators and Factors Affecting Menstrual Cycle Pattern among Sudanese Women with Thyroid Dysfunction
Current Women`s Health Reviews Benzodiazepines, Amphetamines, Testosterone, and Sildenafil as New Candidate Drugs for Sexual Interest, Desire and/or Arousal Disorder
Current Psychopharmacology Ginger and Heart Health: From Mechanisms to Therapeutics
Current Molecular Pharmacology Endothelin Receptors in Gastrointestinal Smooth Muscle
Current Protein & Peptide Science Immune System Alterations by Aldosterone During Hypertension: From Clinical Observations to Genomic and Non-Genomic Mechanisms Leading to Vascular Damage
Current Molecular Medicine Mutations of mtDNA in some Vascular and Metabolic Diseases
Current Pharmaceutical Design