Abstract
In this review, we debate the evidence for abnormal white matter microstructure and myelination in bipolar disorder, as mainly detected by diffusion tensor imaging (DTI) studies. The effects of mood stabilizers on white matter are discussed, based on available findings from human and animal studies. Last, perspectives in this field of research are also drawn.
Keywords: Diffusion imaging, white matter, prefrontal cortex, hippocampus, amygdala, corpus callosum, lithium, valproate
Current Pharmaceutical Design
Title: Myelination in Bipolar Patients and the Effects of Mood Stabilizers on Brain Anatomy
Volume: 15 Issue: 22
Author(s): Paolo Brambilla, Marcella Bellani, Ping-Hong Yeh and Jair C. Soares
Affiliation:
Keywords: Diffusion imaging, white matter, prefrontal cortex, hippocampus, amygdala, corpus callosum, lithium, valproate
Abstract: In this review, we debate the evidence for abnormal white matter microstructure and myelination in bipolar disorder, as mainly detected by diffusion tensor imaging (DTI) studies. The effects of mood stabilizers on white matter are discussed, based on available findings from human and animal studies. Last, perspectives in this field of research are also drawn.
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Cite this article as:
Brambilla Paolo, Bellani Marcella, Yeh Ping-Hong and Soares C. Jair, Myelination in Bipolar Patients and the Effects of Mood Stabilizers on Brain Anatomy, Current Pharmaceutical Design 2009; 15 (22) . https://dx.doi.org/10.2174/138161209788957519
DOI https://dx.doi.org/10.2174/138161209788957519 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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