Abstract
L-dopa is the most effective drug in the symptomatic management of PD and extends the life span of PD patients.The question whether L-dopa is neurotoxic remains however unresolved. In recent years, increased Homocysteine (Hcy) levels have been observed in L-dopa treated Parkinsons disease (PD) patients, resulting from L-dopa O-methylation by the enzyme catechol-O-methyltransferase. This review summarizes current evidences supporting the possible role of Hcy as mediator of L-dopa toxicity mainly on dopaminergic neurons.
Keywords: Homocysteine, Levodopa, Parkinson's disease, toxicity, dopaminergic neurons
Letters in Drug Design & Discovery
Title: L-Dopa Related Hyperhomocysteinemia: A Possible Mediator of Toxicity?
Volume: 2 Issue: 7
Author(s): Stefano Zoccolella, Giovanni Iliceto, Michele deMari, Giovanni Defazio, Paolo Livrea and Paolo Lamberti
Affiliation:
Keywords: Homocysteine, Levodopa, Parkinson's disease, toxicity, dopaminergic neurons
Abstract: L-dopa is the most effective drug in the symptomatic management of PD and extends the life span of PD patients.The question whether L-dopa is neurotoxic remains however unresolved. In recent years, increased Homocysteine (Hcy) levels have been observed in L-dopa treated Parkinsons disease (PD) patients, resulting from L-dopa O-methylation by the enzyme catechol-O-methyltransferase. This review summarizes current evidences supporting the possible role of Hcy as mediator of L-dopa toxicity mainly on dopaminergic neurons.
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Cite this article as:
Zoccolella Stefano, Iliceto Giovanni, deMari Michele, Defazio Giovanni, Livrea Paolo and Lamberti Paolo, L-Dopa Related Hyperhomocysteinemia: A Possible Mediator of Toxicity?, Letters in Drug Design & Discovery 2005; 2 (7) . https://dx.doi.org/10.2174/157018005774479113
DOI https://dx.doi.org/10.2174/157018005774479113 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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