Abstract
This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT1D receptor. The field of 5-HT1D agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT1D receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.
Keywords: 5-HT1D agonist, 5-HT1D antagonist, serotonin receptor, 5-HT receptor
Current Topics in Medicinal Chemistry
Title: Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands
Volume: 10 Issue: 5
Author(s): Simon E. Ward and Jeannette M. Watson
Affiliation:
Keywords: 5-HT1D agonist, 5-HT1D antagonist, serotonin receptor, 5-HT receptor
Abstract: This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT1D receptor. The field of 5-HT1D agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT1D receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.
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Cite this article as:
Ward Simon E. and Watson Jeannette M., Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands, Current Topics in Medicinal Chemistry 2010; 10 (5) . https://dx.doi.org/10.2174/156802610791111533
DOI https://dx.doi.org/10.2174/156802610791111533 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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