Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors

Title: Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors

Volume: 7 Issue: 6

Author(s): Yubin Wang, Hai Qian, Jinpei Zhou, Huibin Zhang, Jianfeng Ji and Wenlong Huang

Affiliation:

Keywords: 2-Azetidinones, cholesterol absorption inhibitor, synthesis, bioactivities, hamsters, cardiovascular research, coronary heart disease (CHD), exogenous pathways, 3-methylglutaryl, 3-hydroxy

Abstract: Twenty-four 2-azetidinone derivatives have been designed and synthesized as cholesterol absorption inhibitors. All new compounds were evaluated for their activity to inhibit cholesterol absorption in hamsters, and most of them showed considerable effects in lowering the levels of total cholesterol in the serum, especially compound 2d, 4a, 4f, 4i and 4j.

Cite this article as:

Wang Yubin, Qian Hai, Zhou Jinpei, Zhang Huibin, Ji Jianfeng and Huang Wenlong, Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors, Medicinal Chemistry 2011; 7 (6) . https://dx.doi.org/10.2174/157340611797928271