Abstract
Galanthus nivalis agglutinin (GNA)-related lectin family, a superfamily of strictly mannose-binding specific lectins widespread among monotyledonous plants, is well-known to possess a broad range of biological functions such as anti-tumor, anti-fungal and anti-viral activities. Growing insights into the investigations of them provide us a principal force to start this review with a variety of evidences to landmark their biological activities, molecular mechanisms and potential therapeutic applications. Herein, we mainly focused on a comprehensive study on a great number of reported GNA-related lectins with the anti-tumor activity. On the trail of such clues, we studied some GNA-related lectins with anti-tumor effects and explored the apoptosis- and autophagy-induced activities and related molecular mechanisms. These inspiring results further provide us more convincing evidence to understand the anti-cancer molecular mechanisms implicated in apoptosis and autophagy. In addition, GNA-related lectins also possess marked anti-HIV activities and the specific molecular mechanisms are also explored herein. To sum up, GNA-related lectin family would play a key role as a potential drug in future therapeutics.
Keywords: GNA-related lectins, anti-tumor activity, apoptosis, autophagy, drug
Current Chemical Biology
Title: Galanthus nivalis Agglutinin (GNA)-Related Lectins: Traditional Proteins, Burgeoning Drugs?
Volume: 3 Issue: 3
Author(s): Chun-yang Li, Liang Meng, Bo Liu and Jin-ku Bao
Affiliation:
Keywords: GNA-related lectins, anti-tumor activity, apoptosis, autophagy, drug
Abstract: Galanthus nivalis agglutinin (GNA)-related lectin family, a superfamily of strictly mannose-binding specific lectins widespread among monotyledonous plants, is well-known to possess a broad range of biological functions such as anti-tumor, anti-fungal and anti-viral activities. Growing insights into the investigations of them provide us a principal force to start this review with a variety of evidences to landmark their biological activities, molecular mechanisms and potential therapeutic applications. Herein, we mainly focused on a comprehensive study on a great number of reported GNA-related lectins with the anti-tumor activity. On the trail of such clues, we studied some GNA-related lectins with anti-tumor effects and explored the apoptosis- and autophagy-induced activities and related molecular mechanisms. These inspiring results further provide us more convincing evidence to understand the anti-cancer molecular mechanisms implicated in apoptosis and autophagy. In addition, GNA-related lectins also possess marked anti-HIV activities and the specific molecular mechanisms are also explored herein. To sum up, GNA-related lectin family would play a key role as a potential drug in future therapeutics.
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Cite this article as:
Li Chun-yang, Meng Liang, Liu Bo and Bao Jin-ku, Galanthus nivalis Agglutinin (GNA)-Related Lectins: Traditional Proteins, Burgeoning Drugs?, Current Chemical Biology 2009; 3 (3) . https://dx.doi.org/10.2174/2212796810903030324
DOI https://dx.doi.org/10.2174/2212796810903030324 |
Print ISSN 2212-7968 |
Publisher Name Bentham Science Publisher |
Online ISSN 1872-3136 |
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